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Showing 1–7 of 7 results
Advanced filters: Author: Egor A. Syroegin Clear advanced filters

  • Macrolide antibiotics halt protein synthesis in a sequence-dependent manner. Here, authors reveal a comprehensive molecular mechanism by which macrolides induce ribosome stalling selectively at Arg/Lys-X-Arg/Lys motifs in growing polypeptide chains.

    • Egor A. Syroegin
    • Elena V. Aleksandrova
    • Yury S. Polikanov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Structure-guided design and component-based synthesis are used to produce iboxamycin, a novel ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria.

    • Matthew J. Mitcheltree
    • Amarnath Pisipati
    • Andrew G. Myers
    Research
    Nature
    Volume: 599, P: 507-512

  • The authors discovered that hygromycin A not only enhances the cell-killing properties of macrolides but also renders them active against resistant bacteria. The provided structures of antibiotic pairs in complex with WT and macrolide-resistant ribosomes rationalize binding cooperativity of these drugs.

    • Chih-Wei Chen
    • Nadja Leimer
    • Maxim S. Svetlov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Synthesis of peptidyl-tRNAs is challenging because there are no enzymes that can directly attach the desired peptide to tRNA. Now it has been shown that a chemoenzymatic approach based on native chemical ligation can be used for the semi-synthesis of peptidyl-tRNAs for structural/biochemical studies of arrested and non-arrested ribosome complexes.

    • Egor A. Syroegin
    • Elena V. Aleksandrova
    • Yury S. Polikanov
    Research
    Nature Chemistry
    Volume: 15, P: 143-153

  • The authors determined a set of structures of the methylase Cfr-methylated 70S ribosome with iboxamycin and tylosin, two antibiotics that evade Cfr-mediated drug resistance, and revealed two distinct mechanisms by which small molecules can maintain their ability to engage the Cfr-methylated ribosome.

    • Elena V. Aleksandrova
    • Kelvin J. Y. Wu
    • Yury S. Polikanov
    Research
    Nature Chemical Biology
    Volume: 20, P: 867-876