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Showing 1–8 of 8 results
Advanced filters: Author: Elena Maspero Clear advanced filters

  • Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-like transition, and results in defective oogenesis and neuronal loss.

    • Valentina Fajner
    • Fabio Giavazzi
    • Simona Polo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Here, the authors describe BioE3, a biotin-based method to discriminate direct substrates of ubiquitin E3 ligases of interest from mere interactors using proximity proteomics. BioE3 responds to chemical treatments, and works with RING- and HECT-type E3s, as well as ubiquitin-likes (e.g., SUMO).

    • Orhi Barroso-Gomila
    • Laura Merino-Cacho
    • James D. Sutherland
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Here authors find and structurally characterize the selective interaction between CLCa and the actin motor protein myosin VI which act together to generate the force that leads to invagination and fission at the apical surface.

    • Matteo Biancospino
    • Gwen R. Buel
    • Simona Polo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • HECT E3 ligases directly catalyze ubiquitin transfer to their substrates. The crystal structure of ubiquitin-loaded Nedd4 HECT domain in complex with ubiquitin is now presented, revealing insights into the mechanisms for catalytic priming and sequential addition and suggesting the basis for Lys63 specificity.

    • Elena Maspero
    • Eleonora Valentini
    • Simona Polo
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 696-701

  • NEDD4 is a key E3 ubiquitin ligase involved in development and cancer, however, specific inhibitors against NEDD4 remain underdeveloped. Here, the authors identify the inhibitory mechanism of norclomipramine and develop covalent inhibitors targeting NEDD4’s non-catalytic cysteine C627, with one compound showing potent inhibition and promising pharmacokinetics, advancing therapeutic strategies against NEDD4-related diseases.

    • Elena Maspero
    • Anna Cappa
    • Simona Polo
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-13

  • In the TGFβ pathway, receptor-activated SMADs (R-SMADs) associate with SMAD4 to regulate transcription. Piccolo and colleagues reveal that the deubiquitylase USP15 is required for TGFβ responses by reversing R-SMAD ubiquitylation and thereby promoting the retention of the SMAD complex at promoters.

    • Masafumi Inui
    • Andrea Manfrin
    • Stefano Piccolo
    Research
    Nature Cell Biology
    Volume: 13, P: 1368-1375