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Two-dimensional materials could be good platforms to study the extremely subtle mechanical behaviors. Here, the authors measure an anomalous isotope effect on the mechanical properties of boron nitride monolayers, originated from ultrafine isotopic nuclear charge.

Twisted bilayer (tb) MoTe₂ is an ideal platform for investigating the fractional quantum anomalous Hall effect but issues related to air sensitivity make the study of its electronic structure experimentally challenging. As a solution, the authors prepare hBN encapsulated tb-MoTe₂ and using micro-angle resolved photoemission spectroscopy determine the band structure. Furthermore, through in-situ alkali metal deposition, they obtain evidence indicating a direct band gap.

The textile industry’s reliance on synthetic dyes is an important source of greenhouse gas emissions. Here the authors describe a process involving sustainable solvents that allows the extraction, purification, and reuse of dyes, as well as the recycling of dye-free fabrics.

Isotope engineering can enhance spin coherence of solid-state defects, such as NV centers in diamond but progress for defects in hBN has been limited. Gong et al. report the optimization of isotopes in hBN and demonstrate improved coherence and relaxation times for the negatively charged boron vacancy centers.

The extent of diversity in deep subsurface mines is not well documented. Here, Borgonie et al.report the discovery of Protozoa, Fungi, Platyhelminthes, Rotifera, Annelida and Arthropoda from 1.4 km below ground, and conclude that their population growth is limited by food rather than oxygen availability.

This study establishes the pig as a complementary model for studying human pancreas development. It shows pigs mimic human developmental tempo, gene regulation, and endocrine cell emergence, offering a valuable large-animal model for developmental biology.

Formation of the energy-producing machinery in the proximal tubule of the nephron is an essential step in differentiation. The authors show that mitochondrial localization depends on LRRK2, the activity of which is modulated by fluid flow.

Anterior Uveitis is a common inflammatory eye disease that can result in vision loss. Here, the authors perform GWAS and whole-exome analyses of Anterior Uveitis to identify the underlying genetics of HLA-B*27 positive and negative forms of the disease.

The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment.

In vitro modelling of the adipose tissue-liver axis can advance understanding and therapy of metabolic disease, including by distinguishing effects of obesity and inflammation. Here, authors develop such a system based on isogenic human iPSCs and interconnected microphysiological devices.

The tunability of electronic properties is a central goal of research into topological semimetals. Here, the authors report Weyl nodal ring states in the magnetic semimetal EuGa₄ and link the nodal ring state to the observed large non-saturating magnetoresistance.

Mass outflow is a common process in astrophysical objects. Here the authors investigate in which conditions an astrophysically-scaled laser-produced plasma flow can be collimated and evolves in the presence of a misaligned external magnetic field.

In biliary tract cancer HER2 alterations correlate with poor prognosis. Here, the authors present the results of a phase II clinical trial reporting the efficacy and safety of the tyrosine kinase inhibitor neratinib in patients with HER2-mutation positive advanced biliary tract cancers.

Large-scale plasma proteomics of 10,527 samples from the Global Neurodegeneration Proteomics Consortium identified shared and disease-specific pathways in Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia.

Point defects in 2D semiconductors have potential for quantum computing applications, but their controlled design and synthesis remains challenging. Here, the authors identify and fabricate a promising quantum defect in 2D WS₂ via high-throughput computational screening and scanning tunnelling microscopy.

The tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors.

The identification of dark states—quantum states that do not interact with photons—in real materials may help to address many unsolved issues in condensed-matter physics. Now, they have been identified in palladium diselenide.

Ca₂RuO₄ is a Mott insulator that becomes a metal when a current is passed through it. Now, the changes in its electronic structure are revealed as this transition takes place.

Transplantation of allogeneic hematopoietic stem cells (HSCs) is the only reported cure of HIV-1. Here, authors describe an autologous HSC transplant therapy with cells engineered for multilayered resistance to HIV-1 through CCR5 knockout and secretion of HIV inhibiting antibodies by B cell progeny.

The authors developed an open-source, low-cost, multi-channel time-tagging module for fluorescence lifetime image scanning microscopy and correlation spectroscopy that can tag in parallel multiple single-photon events with 30 ps precision.

Applications of laser-plasma accelerated protons in fundamental, applied and medical sciences crucially depend on the creation of stable collimated beams with high repetition rates. Here the authors demonstrate the generation of multi-MeV protons at 5 Hz, with low (degree-level) proton beam divergence from a laser pulse focused onto a water sheet target, potentially mitigating the need for beam capturing techniques.

A back-bending band structure and an emerging pseudogap are observed at the interface between a crystalline solid (black phosphorus) and disordered alkali-metal dopants.

Liu et al. demonstrate that human-driven soil contamination in natural areas mirrors that in nearby urban greenspaces globally, and highlight the potential influence that soil contaminants have on ecosystem functions.

Experiments that directly probe the quantum geometric tensor in solids have not been reported. Now, the quantum metric and spin Berry curvature—dual components of the quantum geometric tensor—have been simultaneously measured in reciprocal space.

An algorithm trained on half a million electronic medical records predicts chronic kidney disease in diabetic patients using a small set of defined clinical features, outperforming predictions derived from clinical trial data.

Stroke is a multifactorial disease influenced by genetic and environmental factors. Here, the authors apply exome-wide association analysis to find rare coding variants associated with stroke in a Pakistani cohort, finding a significant association of a variant in NOTCH3 that is highly enriched in South Asians.

A photonic topological edge state, achieved by employing hexagonal boron nitride and patterned gold films, confines light four orders of magnitude below the diffraction limit while preserving a high quality factor.

Atomically thin materials can form ionic sieves, in which certain species pass through the films, and others are prevented. Here, the authors synthesize nanoporous membranes using chemical vapor deposition and electrochemistry and reveal the mechanism behind the large ion selectivity they observe.

Topological states in atomically thin quantum spin Hall insulators suffer from instability against environmental factors. Here, the authors devise a strategy to preserve topologically protected states in monolayer indenene through graphene intercalation.

Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overlap with other autoimmune diseases.

Angle-resolved photoemission spectroscopy of CaNi₂ shows a band with vanishing dispersion across the full 3D Brillouin zone that is identified with the pyrochlore flat band as well as two additional flat bands that arise from multi-orbital interference of Ni d-electrons.

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

Predicting properties at the interface of materials is crucial for advanced materials design. Here, the authors introduce a high-throughput computational framework, InterMatch, for predicting several properties of an interface by using the databases of individual bulk materials.

Environmental drivers of soil carbon and its sensitivity to warming are poorly understood. The authors compare soil samples of paired urban and natural ecosystems and show that under warming, the microbiome is an essential driver of soil carbon in urban greenspace compared with natural ecosystems.

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Far-field mid-infrared spectroscopy reveals both the electroluminescence of hyperbolic phonon polaritons of hexagonal boron nitride excited by strongly biased graphene, and the associated radiative energy transfer through the material.

Metaplastic breast cancer is a highly chemoresistant breast cancer subtype with limited therapeutic options. Here, the authors report that the NOS inhibitor, L-NMMA, sensitises metaplastic breast cancer to a selective PI3K inhibitor, alpelisib, and taxane chemotherapy via repression of c-JUN mediated epithelial-to-mesenchymal transition.

Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering of T cell engaging bispecific protein able to selectively target cancer cells with a high-frequency mutation in the KRAS oncogene.

Henderson et al. use quantitative pathology mapping and network modeling to show that α-synuclein pathology spreads through a neuroanatomically connected network, guided by selective vulnerability and genetic risk factors.

Here the authors describe that the human origin recognition complex subunit 1 (ORC1) binds to RNAs transcribed from genes with origins of replication at their TSS impacting origin activation.

DNA demethylation is known to be critical for the development and function of many tissues. Here the authors show that it is also required for intestinal lineage differentiation, and that mice lacking DNA demethylases have altered microbiomes and a predisposition to inflammation.

In a widespread sampling campaign across urban soils, the authors find that soil biodiversity, but not plant diversity, is positively related to multiple ecosystem functions in urban environments.

Films of the correlated oxide NdNiO₃ form a metallic antiferromagnetic phase that can be identified using electrical currents, raising the prospect of applications in spintronics.

Rabi dynamics between the ground state and an excited state in helium atoms are generated using femtosecond extreme-ultraviolet pulses from a seeded free-electron laser, which may allow ultrafast manipulation of coherent processes at short wavelengths.

Stem-cell-specific genes regulate processes such as maintenance, identity and/or division. Here, the authors show that in the Arabidopsis root TCX2, a gene expressed across different stem cell populations (a stem-cell-ubiquitous gene), controls division and identity by regulating stem-cell-type-specific networks.

Some anticancer drugs target cell microtubules inhibiting mitosis and cell division. Here, the authors show that CRMP2 induces microtubule bundling and that this activity is regulated by the FER kinase, thus providing a rationale for targeting FER in combination with microtubule-targeting drugs.