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Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation

Blanpain and colleagues delineate lineage reprogramming following PTEN deletion in different prostate cancer-originating cells, demonstrating that in basal cells the NF-κB pathway and innate immunity control stem cell plasticity and tumor initiation.

Chen Jiang
Yura Song
Cédric Blanpain
Research23 Jun 2025
Nature Cancer

Volume: 6, P: 1537-1558
Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice

The mechanisms regulating multipotency in glandular epithelia remain unclear. Here, the authors identify the key role of collagen signaling and ECM stiffness in regulating stem cell multipotency in glandular epithelia.

Chen Jiang
Alessia Centonze
Cédric Blanpain
ResearchOpen Access18 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Giafaglione et al. define metabolic regulation of prostate epithelial lineage identity and show that modulation of lactate metabolism alters response to antiandrogen therapy.

Jenna M. Giafaglione
Preston D. Crowell
Andrew S. Goldstein
ResearchOpen Access04 Dec 2023
Nature Cell Biology

Volume: 25, P: 1821-1832
Heterotypic cell–cell communication regulates glandular stem cell multipotency

The multipotency of basal stem cells is directly regulated by luminal cells through the secretion of TNF, and, following luminal cell ablation, the Notch, Wnt and EGFR signalling pathways reactivate basal cell multipotency.

Alessia Centonze
Shuheng Lin
Cédric Blanpain
Research26 Aug 2020
Nature

Volume: 584, P: 608-613
Prostate luminal progenitor cells: from mouse to human, from health to disease

In this Review, Baures et al. discuss prostate luminal progenitor cells, covering their functional properties and potential role in prostate pathology. In addition, the authors describe different approaches to classifying these cells, and unify multiple identifiers that have been used to define prostate luminal progenitor cells.

Manon Baures
Charles Dariane
Vincent Goffin
Reviews25 Jan 2022
Nature Reviews Urology

Volume: 19, P: 201-218

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Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation

Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice

Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Heterotypic cell–cell communication regulates glandular stem cell multipotency

Prostate luminal progenitor cells: from mouse to human, from health to disease

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