The self-seeding model provides a new paradigm whereby progression from a primary tumor to metastasis is understood as a multidirectional process, balanced between mitotic (primary tumor), seeding (metastasis) and self-seeding processes. The authors discuss how this model helps to explain various enigmas including the similarities between pre-neoplasia and invasive cancer, mammographic breast density as a risk factor, and the relationship between local control and distant recurrence.
- Elizabeth Comen
- Larry Norton
- Joan Massagué
