Nature Search

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

Selenium and copper are two essential trace elements whose homeostasis and distribution is regulated by hepatic release of selenoprotein P (SELENOP) and ceruloplasmin, respectively. Here, the authors show that excessive copper results in hepatic SELENOP accumulation in the trans Golgi which might limit the selenium transport to peripheral organs.

Maria Schwarz
Caroline E. Meyer
Anna P. Kipp
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Template-independent enzymatic synthesis of RNA oligonucleotides

Single-stranded RNA is enzymatically synthesized without use of a template strand.

Daniel J. Wiegand
Jonathan Rittichier
George M. Church
ResearchOpen Access12 Jul 2024
Nature Biotechnology

Volume: 43, P: 762-772
Neoadjuvant anti-PD-1 alone or in combination with anti-TIGIT or an oncolytic virus in resectable stage IIIB–D melanoma: a phase 1/2 trial

In an ongoing adaptive-design trial exploring different combinations of neoadjuvant immunotherapies including the anti-PD-1 agent pembrolizumab, the anti-TIGIT agent vibostolimab and the oncolytic virus gebasaxturev, neoadjuvant pembrolizumab-based regimens elicited encouraging clinical responses in patients with resectable melanoma.

Reinhard Dummer
Caroline Robert
Georgina V. Long
ResearchOpen Access07 Jan 2025
Nature Medicine

Volume: 31, P: 144-151
The AP-1 factor JUNB correlates with poor survival of patients with esophageal adenocarcinoma

Nikolai Schleussner
Karl Knipper
Thomas Schmidt
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Understanding resilience in medical interns through ecological momentary assessments, predictive modelling, and topic analysis

Meine, McPherson et al. assess risk and resilience factors in Swiss medical interns predicting skills improvement, burnout, wellbeing and career motivation. Based on quantitative and qualitative analyses, three important factors emerge: work dissatisfaction, social and team factors and degree of practical involvement.

Laura E. Meine
Ella B. A. McPherson
Birgit Kleim
ResearchOpen Access24 Oct 2025
Communications Medicine

Volume: 5, P: 1-13
Prediction models show differences in highly pathogenic avian influenza outbreaks in Japan and South Korea compared to Europe

Lene Jung Kjær
Carsten Thure Kirkeby
Michael P. Ward
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-14
Site-1 protease is a negative regulator of sarcolipin promoter activity

Sarcolipin expression is transcriptionally induced through a CREB DNA-binding site on its promoter and is suppressed by a site-1 protease-ATF6 axis.

Isha Sharma
Meredith O. Kelly
Rita T. Brookheart
ResearchOpen Access24 Sept 2025
Communications Biology

Volume: 8, P: 1-10
Using surveillance data for early warning modelling of highly pathogenic avian influenza in Europe reveals a seasonal shift in transmission, 2016–2022

Lene Jung Kjær
Michael P. Ward
Carsten Thure Kirkeby
ResearchOpen Access16 Sept 2023
Scientific Reports

Volume: 13, P: 1-16
Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley

Nils Stein, Ehud Weiss, Tzion Fahima, Johannes Krause and colleagues report the genome sequences of 6,000-year-old barley grains obtained from desert caves in Israel. They compare these to whole-exome sequences of a modern barley diversity panel to explore domestication and migration patterns, finding evidence for prehistoric gene flow between wild and cultivated populations.

Martin Mascher
Verena J Schuenemann
Nils Stein
Research18 Jul 2016
Nature Genetics

Volume: 48, P: 1089-1093
Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

Chronic obstructive pulmonary disease (COPD) is now known to be a heterogeneous disorder, hence the pressing need to develop imaging biomarkers to differentiate between the broad range of COPD phenotypes–all of which require different treatments. Here, Craig Galban and his colleagues have adapted the parametric response map technique for the voxel-by-voxel classification analysis of CT lung images taken from a national COPD trial, providing a more objective characterization of the phenotypic contributions of functional small airways disease and emphysema in COPD.

Craig J Galbán
Meilan K Han
Brian D Ross
Research07 Oct 2012
Nature Medicine

Volume: 18, P: 1711-1715
Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients

Raffaela Barbano
Barbara Pasculli
Paola Parrella
ResearchOpen Access27 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Imaging the electrical activity of organelles in living cells

Matamala et al. adapt a hybrid-FRET voltage sensor to enable the recording of resting membrane potential of different organelle compartments in living cells. Their approach allows simple and precise subcellular targeting, the ability to record from individual organelles, and the potential for optical multiplexing of organellar activity.

Ella Matamala
Cristian Castillo
Sebastian E. Brauchi
ResearchOpen Access23 Mar 2021
Communications Biology

Volume: 4, P: 1-12
Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A

The cell-autonomous effect of five severe loss- or gain-of-function GluN2A (NMDA receptor) mutations is assessed on evoked NMDAR-mediated synaptic currents in CA1 pyramidal neurons in cultured mouse hippocampal slices. Data and modelling suggest that mutant-like NMDA-EPSCs can lead to abnormal temporal summation and spine calcium dynamics.

Marwa Elmasri
Daniel William Hunter
Andrew. Charles Penn
ResearchOpen Access28 Feb 2022
Communications Biology

Volume: 5, P: 1-17
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Prolonged Effects of Repeated Social Defeat Stress on mRNA Expression and Function of μ-Opioid Receptors in the Ventral Tegmental Area of Rats

Ella M Nikulina
Klaus A Miczek
Ronald P Hammer Jr
Research19 Jan 2005
Neuropsychopharmacology

Volume: 30, P: 1096-1103
Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Magdalena Koczkowska
Tom Callens
Ludwine M. Messiaen
ResearchOpen Access07 Sept 2018
Genetics in Medicine

Volume: 21, P: 867-876
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

Nada A. Al-Tassan
Nicola Whiffin
Richard S. Houlston
ResearchOpen Access20 May 2015
Scientific Reports

Volume: 5, P: 1-11
Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus

Jieshi Yu
Chithra Sreenivasan
Dan Wang
ResearchOpen Access01 Feb 2021
npj Vaccines

Volume: 6, P: 1-5
Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

Nada A. Al-Tassan
Nicola Whiffin
Richard S. Houlston
Amendments and Corrections03 Aug 2015
Scientific Reports

Volume: 5, P: 1
Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Magdalena Koczkowska
Tom Callens
Ludwine M. Messiaen
Amendments and Corrections02 Oct 2018
Genetics in Medicine

Volume: 21, P: 764-765
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

David Jarvis
Jonathan S Mitchell
Richard S Houlston
ResearchOpen Access23 Jun 2016
British Journal of Cancer

Volume: 115, P: 266-272

Search

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

Template-independent enzymatic synthesis of RNA oligonucleotides

Neoadjuvant anti-PD-1 alone or in combination with anti-TIGIT or an oncolytic virus in resectable stage IIIB–D melanoma: a phase 1/2 trial

The AP-1 factor JUNB correlates with poor survival of patients with esophageal adenocarcinoma

Understanding resilience in medical interns through ecological momentary assessments, predictive modelling, and topic analysis

Prediction models show differences in highly pathogenic avian influenza outbreaks in Japan and South Korea compared to Europe

Site-1 protease is a negative regulator of sarcolipin promoter activity

Using surveillance data for early warning modelling of highly pathogenic avian influenza in Europe reveals a seasonal shift in transmission, 2016–2022

Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley

Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients

Imaging the electrical activity of organelles in living cells

Common synaptic phenotypes arising from diverse mutations in the human NMDA receptor subunit GluN2A

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Prolonged Effects of Repeated Social Defeat Stress on mRNA Expression and Function of μ-Opioid Receptors in the Ventral Tegmental Area of Rats

Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus

Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

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