Nature Search

How a lab happiness programme is helping me through the COVID-19 crisis

I was cynical at first, but it’s proved a powerful tool, says Ellen J. Wehrens.

Ellen J. Wehrens
Comments & Opinion04 Jun 2020
Nature
T cells out of control—impaired immune regulation in the inflamed joint

In this Review, the authors summarize the latest findings on changes in effector T-cell homeostasis in autoimmune disease and discuss how mechanisms that normally regulate these cells are affected in the inflamed joints of patients with arthritis. The clinical implications of these findings are also described.

Ellen J. Wehrens
Berent J. Prakken
Femke van Wijk
Reviews18 Sept 2012
Nature Reviews Rheumatology

Volume: 9, P: 34-42
De novo H3.3K27M-altered diffuse midline glioma in human brainstem organoids to dissect GD2 CAR T cell function

Bessler et al. developed a human organoid model for H3.3K27M-altered diffuse midline glioma that recapitulates key tumor features and demonstrated its utility for modeling CAR T cell and microglia functions.

Nils Bessler
Amber K. L. Wezenaar
Anne C. Rios
ResearchOpen Access05 Jan 2026
Nature Cancer

P: 1-18
Uncovering the mode of action of engineered T cells in patient cancer organoids

The dynamics and molecular mechanisms of T cell therapies are probed in cancer organoids.

Johanna F. Dekkers
Maria Alieva
Anne C. Rios
ResearchOpen Access25 Jul 2022
Nature Biotechnology

Volume: 41, P: 60-69
Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D

An imaging software for large-scale microscopy data shows how cells are organized in tissues.

Ravian L. van Ineveld
Michiel Kleinnijenhuis
Anne C. Rios
Research03 Jun 2021
Nature Biotechnology

Volume: 39, P: 1239-1245
Early transcriptional and epigenetic regulation of CD8⁺ T cell differentiation revealed by single-cell RNA sequencing

CD8⁺ T cells rapidly commence transcriptional changes after antigenic encounter and priming. Yeo and colleagues find substantial transcriptional heterogeneity among responding lymphocytes, particularly at the first division, that influences cell fate.

Boyko Kakaradov
Janilyn Arsenio
Gene W Yeo
Research20 Feb 2017
Nature Immunology

Volume: 18, P: 422-432
Bridging live-cell imaging and next-generation cancer treatment

Live-cell imaging can provide spatial, morphological and molecular understanding of cancer response to treatment. Here, Alieva et al. review its recent application for uncovering drug mode of action and tumour heterogeneity in response to treatment and discuss its application for next-generation precision medicine.

Maria Alieva
Amber K. L. Wezenaar
Anne C. Rios
Reviews13 Sept 2023
Nature Reviews Cancer

Volume: 23, P: 731-745
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

BEHAV3D is a 3D live imaging platform for analyzing engineered T cell behavior and tumor response. This provides insights into the mode of action of cellular immunotherapy, capturing heterogeneity within and between tumors during treatment response.

Maria Alieva
Mario Barrera Román
Anne C. Rios
Protocols19 Mar 2024
Nature Protocols

Volume: 19, P: 2052-2084
High-resolution 3D imaging of fixed and cleared organoids

This protocol for clearing and high-resolution 3D imaging of entire organoids expressing fluorescence reporters or following immunolabeling enables confocal, super-resolution confocal, multiphoton and light-sheet microscopy to be performed.

Johanna F. Dekkers
Maria Alieva
Anne C. Rios
Protocols03 May 2019
Nature Protocols

Volume: 14, P: 1756-1771
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids

Dekkers et al. provide a toolbox for the long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids.

Johanna F. Dekkers
Esmée J. van Vliet
Anne C. Rios
Protocols10 Mar 2021
Nature Protocols

Volume: 16, P: 1936-1965
Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D

Multispectral large-scale single-cell resolution 3D imaging allows up to eight fluorophores to be captured in a single acquisition. This protocol enables the visualization and exploration of large intact tissue volumes.

Ravian L. van Ineveld
Raphaël Collot
Anne C. Rios
Protocols30 Sept 2022
Nature Protocols

Volume: 17, P: 3028-3055
Anti-GD2-IRDye800CW as a targeted probe for fluorescence-guided surgery in neuroblastoma

Lianne M. Wellens
Marion M. Deken
Anne C. Rios
ResearchOpen Access19 Oct 2020
Scientific Reports

Volume: 10, P: 1-12

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