Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a previously unappreciated, system-wide remodelling of nucleotide metabolism driven by nitric oxide (NO), with important implications for inflammatory macrophage function and host–pathogen interactions.
- Eloïse Marques
- Dylan G. Ryan
