In this study, the authors show that neuronal activity, induced by natural exploration, exposure to visual stimuli or optogenetic probe–mediated stimulation, can induce double-stranded DNA breaks (DSBs) in neurons. The numbers of these DSBs were aggravated in the presence of amyloid precursor protein and depended on extrasynaptic NMDAR activity.
- Elsa Suberbielle
- Pascal E Sanchez
- Lennart Mucke
