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Showing 1–2 of 2 results
Advanced filters: Author: Emerald Nguyen Clear advanced filters

  • Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

    • Shangming Tang
    • Sara Hariri
    • Neil Hunter
    ResearchOpen Access
    Nature
    Volume: 647, P: 776-785

  • Binding of the small-molecule inhibitor CGI1746 to Bruton's tyrosine kinase (Btk), a therapeutic target for rheumatoid arthritis, induces an inactive Btk conformation. Application of this specific chemical probe reveals two Btk signaling pathways involved in inflammatory arthritis.

    • Julie A Di Paolo
    • Tao Huang
    • Kevin S Currie
    Research
    Nature Chemical Biology
    Volume: 7, P: 41-50