Nature Search

Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding

Guang-da Lin
Debasish Chattopadhyay
Sthanam V.L. Narayana
Research01 Jul 1997
Nature Structural Biology

Volume: 4, P: 539-547
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Maternofetal Transmission of IgG-Bound Hepatitis B e Antigen

Koshu Arakawa
Fumio Tsuda
Makoto Mayumi
Research01 Mar 1982
Pediatric Research

Volume: 16, P: 247-250
Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons

Sarah Ritzenthaler
Emiko Suzuki
Akira Chiba
Research01 Oct 2000
Nature Neuroscience

Volume: 3, P: 1012-1017
Diapolycopenedioic Acid Xylosyl Esters A, B, and C, Novel Antioxidative Glyco-C₃₀-carotenoic Acids Produced by a New Marine Bacterium Rubritalea squalenifaciens

Kazutoshi Shindo
Emiko Asagi
Takashi Maoka
Research01 Mar 2008
The Journal of Antibiotics

Volume: 61, P: 185-191
Identification of a dual orange/far-red and blue light photoreceptor from an oceanic green picoplankton

Blue light penetrates deeper than red light in ocean, thus blue light sensing is critical for adaptation to marine environments. Here, the authors report the genome of Pyconococcus provasolii and identify a chimeric dual orange/far-red and blue light receptor composed of a phytochrome and a cryptochrome by analyzing the marine metagenomes.

Yuko Makita
Shigekatsu Suzuki
Minami Matsui
ResearchOpen Access16 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Author Correction: Identification of a dual orange/far-red and blue light photoreceptor from an oceanic green picoplankton

Yuko Makita
Shigekatsu Suzuki
Minami Matsui
Amendments and CorrectionsOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Time-varying overdispersion of SARS-CoV-2 transmission during the periods when different variants of concern were circulating in Japan

Yura K. Ko
Yuki Furuse
Hitoshi Oshitani
ResearchOpen Access14 Aug 2023
Scientific Reports

Volume: 13, P: 1-8
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2

Hoshino et al., engineer a human virus receptor, hACE2, and demonstrate its potential for overcoming SARS-CoV-2 mutations that otherwise hinder therapeutic interventions. Overall, the data provide insights in to the therapeutic potential of engineered receptors.

Yusuke Higuchi
Tatsuya Suzuki
Atsushi Hoshino
ResearchOpen Access21 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

Galectin-3 (Gal-3) has been proposed to have a pathogenic role in systemic sclerosis (SSc). Here, the authors identify a Gal-3-based transcriptomic signature associated with SSc severity in patients and demonstrate that Gal-3 blockade reduces the severity of SSc skin and lung lesions in murine models.

Céline Ortega-Ferreira
Perrine Soret
Frédéric De Ceuninck
ResearchOpen Access31 Aug 2023
Nature Communications

Volume: 14, P: 1-20
Tumor B7-H3 expression in diagnostic biopsy specimens and survival in patients with metastatic prostate cancer

Gulanbar Amori
Emiko Sugawara
Kentaro Inamura
Research08 Feb 2021
Prostate Cancer and Prostatic Diseases

Volume: 24, P: 767-774
Non-Helicobacter pylori Helicobacter (NHPH) positive gastric cancer

Tomohiko Yasuda
Hyun Seok Lee
Sachiyo Nomura
ResearchOpen Access21 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Cancer predisposition genes in Japanese children with rhabdomyosarcoma

Hiroko Fukushima
Ryoko Suzuki
Hidetoshi Takada
Research14 Jul 2021
Journal of Human Genetics

Volume: 67, P: 35-41
O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell–matrix interactions

The modification of proteins with O-linked-N-acetylglucosamine causes regulation of multiple cellular processes. In this study, Sakaidani and colleagues identify an endoplasmic reticulum O-linked-N-acetylglucosamine transferase in Drosophilathat regulates the adhesion of epithelial cells to the extracellular matrix.

Yuta Sakaidani
Tomoko Nomura
Tetsuya Okajima
Research13 Dec 2011
Nature Communications

Volume: 2, P: 1-9
Effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident

Hideaki Yamashiro
Yasuyuki Abe
Manabu Fukumoto
ResearchOpen Access08 Oct 2013
Scientific Reports

Volume: 3, P: 1-6
Segmented Poly(urethane-urea)s Synthesized Directly from Isocyanate-Terminated Prepolymers and Masked Diamines III. Kinetic and Mechanistic Study on Polymerization Reactions

Hiroyuki Hanahata
Emiko Yamazaki
Yoshiharu Kitahama
Research01 Oct 1997
Polymer Journal

Volume: 29, P: 826-835
Solvent-free autocatalytic supramolecular polymerization

The solvent-free conversion of phthalonitrile derivatives into phthalocyanines in the bulk is described, involving a reductive cyclotetramerization step and the formation of one-dimensional single-crystalline fibres. This solvent-free autocatalytic supramolecular polymerization may enable for a sustainable fabrication of multi-block supramolecular copolymers.

Zhen Chen
Yukinaga Suzuki
Takuzo Aida
Research14 Oct 2021
Nature Materials

Volume: 21, P: 253-261
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

Susan Tsunoda
Jimena Sierralta
Charles S. Zuker
Research17 Jul 1997
Nature

Volume: 388, P: 243-249
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease

Joung Soon Jang
Su Jae Lee
Jane B Trepel
Research15 Mar 1999
Oncogene

Volume: 18, P: 1789-1796
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age

Hisato Suzuki
Hiroko Fukushima
Ryo Sumazaki
Research19 May 2016
Journal of Human Genetics

Volume: 61, P: 797-801
Hemodialysis employing molecular hydrogen (H₂) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism

Masaaki Nakayama
Kimio Watanabe
Michiko Suzuki
ResearchOpen Access11 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Emiko Sato
Takefumi Mori
Sadayoshi Ito
ResearchOpen Access10 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study

Hisako Enomoto
Kenji Hirata
Emiko Noguchi
Research01 Jul 2008
Journal of Human Genetics

Volume: 53, P: 615-621
A novel assay of bacterial peptidoglycan synthesis for natural product screening

Ryo Murakami
Yasunori Muramatsu
Fujio Isono
Research20 Feb 2009
The Journal of Antibiotics

Volume: 62, P: 153-158
CXCL4/PF4 is a predictive biomarker of cardiac differentiation potential of human induced pluripotent stem cells

Fumiya Ohashi
Shigeru Miyagawa
Yoji Sato
ResearchOpen Access15 Mar 2019
Scientific Reports

Volume: 9, P: 1-15
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Structural and biophysical studies of the inhibition of bacterial serine hydroxymethyltransferase (SHMT) by a human SHMT inhibitor used for cancer therapy, (+)-SHIN-1, identify SHMT as a potent antibacterial target.

Yuko Makino
Chihiro Oe
Eiichi N. Kodama
ResearchOpen Access23 Jun 2022
Communications Biology

Volume: 5, P: 1-12
How potassium intake regulates sodium excretion in the kidney? Aldosterone-independent pathway in human

Hiromi Nakagawa
Emiko Kuribayashi-Okuma
Tatsuo Shimosawa
Correspondence14 Feb 2025
Hypertension Research

Volume: 48, P: 1675-1676
Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Ryoko Kibe
Shin Kurihara
Mitsuharu Matsumoto
ResearchOpen Access01 Apr 2014
Scientific Reports

Volume: 4, P: 1-11
⁹⁰Sr in teeth of cattle abandoned in evacuation zone: Record of pollution from the Fukushima-Daiichi Nuclear Power Plant accident

Kazuma Koarai
Yasushi Kino
Hisashi Shinoda
ResearchOpen Access05 Apr 2016
Scientific Reports

Volume: 6, P: 1-9
Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells

Ryo Ohta
Akira Niwa
Megumu K. Saito
ResearchOpen Access02 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells

Chiharu Okuda
Yuto Ueda
Takao Kataoka
Research30 Mar 2023
The Journal of Antibiotics

Volume: 76, P: 324-334
Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein

Mayumi Kawada
Chun-Chuan Chen
Emiko Mizoguchi
Research19 May 2008
Laboratory Investigation

Volume: 88, P: 883-895
The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B

Kizuki Watanabe
Shin-ya Nishio
Shunsuke Kondo
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
Citizen science via social media revealed conditions of symbiosis between a marine gastropod and an epibiotic alga

Osamu Kagawa
Shota Uchida
Ryoya Sugimoto
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-10

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