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Showing 1–4 of 4 results
Advanced filters: Author: Emil Marklund Clear advanced filters

  • Single-molecule fluorescence resonance energy transfer and real-time confocal laser tracking with fluorescence correlation spectroscopy together characterize how individual lac repressor molecules bypass operator sites while exploring the DNA surface at microsecond timescales.

    • Emil Marklund
    • Brad van Oosten
    • Sebastian Deindl
    Research
    Nature
    Volume: 583, P: 858-861

  • DNA thermodynamics underlies many biological and biotechnological applications but is challenging to accurately predict. Here, the authors develop a high-throughput DNA melting method and improve computational models for predicting DNA folding energies from sequence data.

    • Yuxi Ke
    • Eesha Sharma
    • William J. Greenleaf
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor binding contribute to gene expression.

    • Benjamin R. Doughty
    • Michaela M. Hinks
    • William J. Greenleaf
    Research
    Nature
    Volume: 636, P: 745-754

  • The vast combinatorial sequence space of RNAs has prohibited quantitative mapping from nucleotide sequence to structure and function. New biochemical methods in vitro, which carry out measurements on hundreds of thousands of molecules at the same time, are now beginning to solve this issue.

    • Emil Marklund
    • Yuxi Ke
    • William J. Greenleaf
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 401-414