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Showing 1–3 of 3 results
Advanced filters: Author: Emily Bordeleau Clear advanced filters

  • Here, the authors describe the mechanistic flexibility and substrate promiscuity of the apramycin resistance enzyme ApmA. They identify additional clinical drugs susceptible to modification through a molecular mechanism that diverges from other enzymes within the left-handed β-helix superfamily.

    • Emily Bordeleau
    • Peter J. Stogios
    • Gerard D. Wright
    Research
    Nature Chemical Biology
    Volume: 20, P: 234-242

  • Acylhydrazones are often found in compounds across screening databases, and numerous bioactive acylhydrazones exist. This functional group can isomerize between E and Z in response to light or upon exposure to thiols. Now, E/Z isomerization is found to impact activities of bioactive acylhydrazones and should be routinely analysed.

    • Zhiwei Zhang
    • Giang N. T. Le
    • G. Andrew Woolley
    Research
    Nature Chemistry
    Volume: 15, P: 1285-1295