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Showing 1–5 of 5 results

Advanced filters: Author: Emily C. Dykhuizen Clear advanced filters

A chemoproteomic portrait of the oncometabolite fumarate

Chemoproteomic mapping of fumarate sensitive cysteines in a hereditary leiomyomatosis and renal cell carcinoma cell line revealed a critical cysteine in the protein–protein interaction interface of the SWI–SNF complex.

Rhushikesh A. Kulkarni
Daniel W. Bak
Jordan L. Meier
Research04 Feb 2019
Nature Chemical Biology

Volume: 15, P: 391-400
BAF complexes facilitate decatenation of DNA by topoisomerase IIα

Mutations in the subunits of BAF chromatin-remodelling complexes are frequently found in human cancer; here deletion of BAF subunits or expression of mutants of the ATPase subunit BRG1 attenuates genome-wide binding of topoisomerase IIα, resulting in tangled chromosomes, anaphase bridges and G2/M arrest.

Emily C. Dykhuizen
Diana C. Hargreaves
Gerald R. Crabtree
Research22 May 2013
Nature

Volume: 497, P: 624-627
Growth factor receptor plasticity drives therapeutic persistence of metastatic breast cancer

Mitchell Ayers
Marvis Monteiro
Michael K. Wendt
ResearchOpen Access04 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-12
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development

Samantha L. Tinsley
Ella Rose D. Chianis
Brittany L. Allen-Petersen
Research23 Oct 2024
Oncogene

Volume: 43, P: 3673-3687
The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail

Tyler M. Weaver
Jiachen Liu
Catherine A. Musselman
ResearchOpen Access30 Jan 2019
Scientific Reports

Volume: 9, P: 1-11