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Showing 1–5 of 5 results
Advanced filters: Author: Emily F. Calderbank Clear advanced filters

  • Recent studies have traced haematopoiesis at the clonal level but lack a way to extract dynamical information. Here, authors develop CLADES, a tool to estimate cellular kinetics and the number of divisions to produce mature cells for each clone, in human cord blood and adult mouse haematopoiesis.

    • Mingze Gao
    • Melania Barile
    • Yuanhua Huang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Haematopoiesis has high clonal diversity up to about 65 years of age, after which diversity drops precipitously owing to positive selection acting on a handful of clones that expand exponentially throughout adulthood.

    • Emily Mitchell
    • Michael Spencer Chapman
    • Peter J. Campbell
    ResearchOpen Access
    Nature
    Volume: 606, P: 343-350

  • Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment to date.

    • Serena Belluschi
    • Emily F. Calderbank
    • Elisa Laurenti
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Single-cell transcriptomic profiling of fetal liver, skin, kidney and yolk sac reveals the differentiation trajectories of human haematopoietic stem cells and multipotent progenitors, which are validated to produce an integrated map of fetal liver haematopoiesis.

    • Dorin-Mirel Popescu
    • Rachel A. Botting
    • Muzlifah Haniffa
    Research
    Nature
    Volume: 574, P: 365-371

  • The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic silencing of the class II transactivator leads to downregulation of HLA-DR in these cells.

    • Jake R. Thomas
    • Anna Appios
    • Naomi McGovern
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16