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Showing 1–2 of 2 results
Advanced filters: Author: Emily S. Sumrall Clear advanced filters

  • Single-molecule tracking reveals nanoscale domains within fused-in-sarcoma condensates. These nanodomains migrate to the condensate surface during ageing, seeding amyotrophic lateral sclerosis-linked fibrils, a process accelerated by small-molecule drugs.

    • Guoming Gao
    • Emily R. Sumrall
    • Nils G. Walter
    Research
    Nature Nanotechnology
    P: 1-10

  • Biomolecular condensates are membraneless compartments that typically contain proteins and RNAs and broadly affect many cell types and organs. In the kidney in particular, rapid and reversible assembly of biomolecular condensates occurs through the process of hyperosmotic phase separation. This Review describes emerging evidence for, and the impact of, biomolecular condensates on kidney physiology and disease.

    • Guoming Gao
    • Emily S. Sumrall
    • Nils G. Walter
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 756-770