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Showing 1–23 of 23 results

Advanced filters: Author: Eng Eong Ooi Clear advanced filters

Publisher Correction: Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Youjia Zhong
Alicia Y. H. Kang
Eng Eong Ooi
Amendments and CorrectionsOpen Access10 Jun 2024
Nature Medicine

Volume: 30, P: 2093
Zika immune imprint risks dengue

Previous Zika virus infection results in the production of anti-NS1 IgA antibodies that complex with soluble NS1 from subsequent dengue virus infection to activate neutrophils, which release pro-inflammatory mediators to exacerbate the risk of severe dengue.

Eng Eong Ooi
News & Views02 Jan 2026
Nature Immunology

Volume: 27, P: 10-11
Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

The dynamics and durability of immune responses associated with protection against symptomatic infection in children offer insights to guide vaccination policies in pediatric populations.

Youjia Zhong
Alicia Y. H. Kang
Eng Eong Ooi
ResearchOpen Access30 Apr 2024
Nature Medicine

Volume: 30, P: 1373-1383
Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

The authors demonstrate the effectiveness of T cells in controlling acute viral infections, without neutralizing antibodies, by conducting an Orthoflavivirus vaccination and challenge study in humans.

Shirin Kalimuddin
Christine Y. L. Tham
Eng Eong Ooi
ResearchOpen Access10 Jan 2025
Nature Microbiology

Volume: 10, P: 374-387
Structure mapping of dengue and Zika viruses reveals functional long-range interactions

Here, the authors provide detailed analyses of viral RNA structure in virions and in infected cells for four dengue virus serotypes and four Zika virus strains, and identify conserved structures that are important for virus replication.

Roland G. Huber
Xin Ni Lim
Yue Wan
ResearchOpen Access29 Mar 2019
Nature Communications

Volume: 10, P: 1-13
A potential silver lining of delaying the second dose

A delayed second dose relative to the standard 3-week schedule for the BNT162b2 mRNA vaccine against SARS-CoV-2 significantly raises the levels of neutralizing antibodies against SARS-CoV-2 variants.

David R. Martinez
Eng Eong Ooi
News & Views21 Feb 2022
Nature Immunology

Volume: 23, P: 349-351
Dengue virus compartmentalization during antibody-enhanced infection

Eugenia Z. Ong
Summer L. Zhang
Eng Eong Ooi
ResearchOpen Access13 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
A systematic approach to the development of a safe live attenuated Zika vaccine

A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse and mosquito models.

Swee Sen Kwek
Satoru Watanabe
Eng Eong Ooi
ResearchOpen Access12 Mar 2018
Nature Communications

Volume: 9, P: 1-13
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity.

Nina Le Bert
Anthony T. Tan
Antonio Bertoletti
Research15 Jul 2020
Nature

Volume: 584, P: 457-462
Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity

Immunization with inactivated Japanese encephalitis vaccine generates cross-reactive antibodies that enhance immunogenicity on subsequent immunization with live attenuated yellow fever vaccine, demonstrating antibody-dependent enhancement of infection in a clinical trial.

Kuan Rong Chan
Xiaohui Wang
Eng Eong Ooi
Research19 Sept 2016
Nature Microbiology

Volume: 1, P: 1-10
Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection

Flaviviruses can cause either symptomatic or asymptomatic infection. Here, symptomatic flavivirus infection associated with a live-attenuated yellow fever viral vaccine was linked to the cellular state before vaccination.

Kuan Rong Chan
Esther Shuyi Gan
Eng Eong Ooi
Research15 Jul 2019
Nature Medicine

Volume: 25, P: 1218-1224
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine

Eugenia Z. Ong
Jia Xin Yee
Kuan Rong Chan
ResearchOpen Access28 Nov 2022
npj Vaccines

Volume: 7, P: 1-9
Author Correction: Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity

Katell Bidet
Victor Ho
Jianzhu Chen
Amendments and CorrectionsOpen Access24 Oct 2019
npj Vaccines

Volume: 4, P: 1
Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest

Raphaël M. Zellweger
Sophie Yacoub
Kevin Tan
ResearchOpen Access26 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
Dengue virus activates cGAS through the release of mitochondrial DNA

Bo Sun
Karin B. Sundström
Eng Eong Ooi
ResearchOpen Access15 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Discordant phylodynamic and spatiotemporal transmission patterns driving the long-term persistence and evolution of human coronaviruses

Marcus G. Mah
Michael A. Zeller
Yvonne C. F. Su
ResearchOpen Access17 Oct 2024
npj Viruses

Volume: 2, P: 1-16
Attenuated dengue viruses are genetically more diverse than their respective wild-type parents

Amanda Makha Bifani
Milly M. Choy
Eng Eong Ooi
ResearchOpen Access20 May 2021
npj Vaccines

Volume: 6, P: 1-8
Molecular determinants of plaque size as an indicator of dengue virus attenuation

Kenneth Choon Meng Goh
Choon Kit Tang
Eng Eong Ooi
ResearchOpen Access17 May 2016
Scientific Reports

Volume: 6, P: 1-11
Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination

Eng Eong Ooi
Arti Dhar
Jenny Guek Hong Low
ReviewsOpen Access02 Mar 2022
npj Vaccines

Volume: 7, P: 1-10
A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine

Jenny G. Low
Ruklanthi de Alwis
Eng Eong Ooi
ResearchOpen Access13 Dec 2022
npj Vaccines

Volume: 7, P: 1-9
Sequential immunization induces strong and broad immunity against all four dengue virus serotypes

Jue Hou
Shubham Shrivastava
Jianzhu Chen
ResearchOpen Access24 Jul 2020
npj Vaccines

Volume: 5, P: 1-11
Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity

Katell Bidet
Victor Ho
Jianzhu Chen
ResearchOpen Access25 Jun 2019
npj Vaccines

Volume: 4, P: 1-13
Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine

David A. G. Skibinski
Leigh Ann Jones
John E. Connolly
ResearchOpen Access20 Dec 2018
Scientific Reports

Volume: 8, P: 1-12