Nature Search

Mosquito–capsid interactions contribute to flavivirus vector specificity

Systemic flavivirus dissemination in mosquitoes following initial infection requires protein–protein interactions within extracellular vesicles, which enable infectious particles to be transported through haemolymph and confer species specificity.

Jichen Niu
Jun Ma
Gong Cheng
Research04 Feb 2026
Nature

P: 1-12
Microbial metabolism amplified warming in three Phanerozoic hyperthermal events

Ancient hyperthermals witnessed a reduction in the transfer efficiency of particulate organic carbon from the surface to the deep ocean due to warming-driven increases in microbial metabolism, which may have amplified this ancient warming.

Yuyang Wu
Haijun Song
Jinnan Tong
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-11
Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

This study identifies monoclonal antibodies A138 and B026 targeting MPXV proteins M1R and B6R. Both antibodies exhibit neutralization of MPXV and VACV, and their combination enhances protective efficacy in mice, supporting a dual-targeting strategy.

Yuanyuan Qu
Wanbo Tai
Gong Cheng
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-16
A unified deep framework for peptide–major histocompatibility complex–T cell receptor binding prediction

UniPMT, a multitask learning model, is presented, which integrates three key biological relationships into a unified framework for accurate peptide–MHC–TCR binding prediction.

Yunxiang Zhao
Jijun Yu
Jiannan Feng
ResearchOpen Access26 Feb 2025
Nature Machine Intelligence

Volume: 7, P: 650-660
GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.

Yumeng Peng
Qiang Zeng
Congwen Wei
ResearchOpen Access01 Dec 2021
Nature Communications

Volume: 12, P: 1-16
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia

Zhong et al. show that the protein GP73 stimulates hepatic glucose production and is induced in response to infection with SARS-CoV-2 in vitro and in vivo, thus proposing a molecular mechanism underlying hyperglycemia associated with COVID-19.

Luming Wan
Qi Gao
Hui Zhong
Research06 Jan 2022
Nature Metabolism

Volume: 4, P: 29-43
Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications

Postoperative abdominal infections have been associated with tumor recurrence and metastasis in patients treated for locally advanced gastric cancer. Here the authors show that infectious complications are associated with the release of neutrophil extracellular traps that facilitate gastric cancer cell extravasation and metastasis formation.

Xiang Xia
Zizhen Zhang
Gang Zhao
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-14
A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection

The authors use lipid nanoparticles (LNPs) that predominantly accumulate in the lung to deliver mRNA encoding for the broadly neutralizing antibody 8-9D, and achieve superior inhibition of SARS-CoV-2 infection in mice compared to control LNPs.

Wanbo Tai
Kai Yang
Gong Cheng
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-17
A predictive language model for SARS-CoV-2 evolution

Enhao Ma
Xuan Guo
Gong Cheng
ResearchOpen Access23 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-17
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2

Patients with diabetes are more susceptible to suffer from more severe COVID-19. Tong et al. identify a glucose-like metabolite that is reduced in patients with diabetes and has the ability to prevent cellular infection by SARS-CoV-2

Liangqin Tong
Xiaoping Xiao
Gong Cheng
Research09 May 2022
Nature Metabolism

Volume: 4, P: 547-558
AMTB, a TRPM8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the TGFβ signaling pathway

Yujie Liu
Ao Leng
Jianru Xiao
ResearchOpen Access31 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-10
Hypoxic gastric cancer-derived exosomes promote progression and metastasis via MiR-301a-3p/PHD3/HIF-1α positive feedback loop

Xiang Xia
Shuchang Wang
Gang Zhao
Research21 Aug 2020
Oncogene

Volume: 39, P: 6231-6244

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