Nature Search

Host control of persistent Epstein–Barr virus infection

Using blood-based genome sequence data, non-genetic and genetic factors associated with control of Epstein–Barr virus during persistent infection are reported.

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
ResearchOpen Access19 Feb 2026
Nature

P: 1-13
Effectiveness of the long-term prism adaptation test over 1 month or more in strabismus surgery for esotropia

Akinari Yamamoto
Manabu Miyata
Akitaka Tsujikawa
ResearchOpen Access04 Jan 2026
Scientific Reports

Volume: 16, P: 1-7
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor

Kappa-opioid receptors (KORs) influence pain and itch. Here, using cryoEM, spectroscopy, and cell tests, the authors show how specific amino acids shape KOR responses. These findings may guide development of pain treatments with fewer side effects.

Chiyo Suno-Ikeda
Ryo Nishikawa
Ryoji Suno
ResearchOpen Access28 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Lifetime risk, sex and age differences in annual incidence of ocular motor cranial nerve palsy in Japan for 2019

Miyata et al. examine the incidence rates and lifetime risk of ocular motor cranial nerve palsy (OMCNP) in in a nationwide, population-based cohort study in Japan for 2019. Finding reveals that OMCNP incidence rate increases with age and is higher in men, and that approximately one in 100 individuals is affected in their lifetime.

Manabu Miyata
Ai Kido
Akitaka Tsujikawa
ResearchOpen Access19 Jul 2025
Communications Medicine

Volume: 5, P: 1-6
Atherosclerosis in CKD: differences from the general population

The prevalence of cardiovascular disease is high in patients with chronic kidney disease (CKD), especially in those with end-stage renal disease. In this Review, Drüeke and Massy discuss the contribution of atherosclerosis to the development of cardiovascular disease in patients with CKD and describe data from clinical, imaging, morphological and experimental studies that provide evidence for atherogenesis as CKD progresses.

Tilman B. Drüeke
Ziad A. Massy
Reviews26 Oct 2010
Nature Reviews Nephrology

Volume: 6, P: 723-735
Long term efficacy of recession and resection for abducens nerve palsy with targeting overcorrection of 5 prism diopters

Akinari Yamamoto
Manabu Miyata
Akitaka Tsujikawa
ResearchOpen Access26 Jun 2025
Scientific Reports

Volume: 15, P: 1-6
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

The stromal fibroblast population in the colon is composed of heterogeneous and distinct cell subtypes that play a crucial role in the development of colitis and colon cancer. Here the authors generate IL-11 reporter mice and characterize the origin and phenotype of inflammatory IL-11⁺ fibroblasts in colitis and colon cancer preclinical models.

Takashi Nishina
Yutaka Deguchi
Hiroyasu Nakano
ResearchOpen Access16 Apr 2021
Nature Communications

Volume: 12, P: 1-20
Differences in the corrective effects of vertical transposition accompanied by recession–resection of the horizontal rectus muscles for complicated vertical deviation

Shin-ya Nakao
Manabu Miyata
Akitaka Tsujikawa
ResearchOpen Access26 Jul 2024
Eye

Volume: 38, P: 3252-3257
Relationship between binocular vision and Govetto’s stage in monocular idiopathic epiretinal membrane

Kanae Tsuda
Manabu Miyata
Akitaka Tsujikawa
ResearchOpen Access03 Sept 2024
Scientific Reports

Volume: 14, P: 1-6
Synergistic effect of obesity on hypertensive renal arteriosclerosis in individuals without chronic kidney disease: A zero-hour biopsy-based cohort study

Hirofumi Okamoto
Yuta Matsukuma
Tetsuro Ago
Research04 Feb 2026
Hypertension Research

Volume: 49, P: 1371-1381
The protective role of conjunctival goblet cell mucin sialylation

Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.

Moe Matsuzawa
Tomoaki Ando
Jiro Kitaura
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Micellization of Random Block Copolymers in a Nonselective Solvent Using α,ω-Diamine

Eri Yoshida
Research01 Jun 2003
Polymer Journal

Volume: 35, P: 484-490
Longitudinal changes in superficial microvasculature in glaucomatous retinal nerve fiber layer defects after disc hemorrhage

Yoko Okamoto
Tadamichi Akagi
Akitaka Tsujikawa
ResearchOpen Access16 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy

Kazuhiro Kobayashi
Yutaka Nakahori
Tatsushi Toda
Research23 Jul 1998
Nature

Volume: 394, P: 388-392
Cellulose intrafibrillar mineralization of biological silica in a rice plant

Eri Nakamura
Noriaki Ozaki
Hiroaki Imai
ResearchOpen Access12 Apr 2021
Scientific Reports

Volume: 11, P: 1-7
Colorectal cancer cell line-derived organoid model with stem cell properties captures the regrowing state of residual cancer cells after neoadjuvant chemotherapy

Kiyotaka Nakano
Eiji Oki
Tatsumi Yamazaki
ResearchOpen Access20 Jun 2025
Cell Death Discovery

Volume: 11, P: 1-14
High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice

Modulation of the gut microbiota in mice with oral treatment of W27 immunoglobulin A had a therapeutic effect on lymphoproliferative disease and colitis models in mice.

Shinsaku Okai
Fumihito Usui
Reiko Shinkura
Research04 Jul 2016
Nature Microbiology

Volume: 1, P: 1-11
Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis

Satoru Tada
Tatsusada Okuno
Hideki Mochizuki
ResearchOpen Access27 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
A genome-wide association between foveal thickness and arrhythmia

Nakao et al. conduct and validate a phenome-wide association study on foveal thickness and find DPF3 (rs4903064) correlates with a reduced risk of arrhythmia, specifically premature cardiac complex, suggesting a link between foveal thickness and cardiovascular health.

Shin-ya Nakao
Masahiro Miyake
Akitaka Tsujikawa
ResearchOpen Access28 Aug 2025
Communications Medicine

Volume: 5, P: 1-7
Aldosterone Nongenomically Produces NADPH Oxidase–Dependent Reactive Oxygen Species and Induces Myocyte Apoptosis

Hironori Hayashi
Miyuki Kobara
Hiroaki Matsubara
Research01 Feb 2008
Hypertension Research

Volume: 31, P: 363-375
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Association of laughter and social communication with oral frailty among residents in Fukushima: a cross-sectional study

Narumi Funakubo
Kanako Okazaki
Tetsuya Ohira
ResearchOpen Access05 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif

Taku Tsukamoto
Masakazu Nakano
Junya Kuroda
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Changes in salivary microbiota due to gastric cancer resection and its relation to gastric fluid microbiota

Eri Komori
Nahoko Kato-Kogoe
Takaaki Ueno
ResearchOpen Access22 Sept 2023
Scientific Reports

Volume: 13, P: 1-11
Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson

Yoshikatsu Hosoda et al. study the genetic basis for central corneal thickness (CCT) that is associated with keratoconus. They identify two susceptibility loci, STON2 rs2371597 and SMAD3 rs12913547, using two-step genome-wide association study (GWAS) and predictive analysis with IBM’s Watson question answering computer system, respectively.

Yoshikatsu Hosoda
Masahiro Miyake
Shinji Kosugi
ResearchOpen Access31 Jul 2020
Communications Biology

Volume: 3, P: 1-9
One-Year Outcome Predictors of Strabismus Surgery from Anterior Segment Optical Coherence Tomography with Multiple B-Scan Averaging

Manabu Miyata
Kenji Suda
Akitaka Tsujikawa
ResearchOpen Access21 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity

Yasuhiro Onogi
Tsutomu Wada
Toshiyasu Sasaoka
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-13
Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells

C Lagadec
E Adriaenssens
X Le Bourhis
Research03 Sept 2007
Oncogene

Volume: 27, P: 1472-1477
Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses

Junko S. Takeuchi
Fengrong Ren
Kei Sato
ResearchOpen Access04 Nov 2015
Scientific Reports

Volume: 5, P: 1-17
Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca²⁺ signaling in human retinal pigment epithelial cells

Rina Ikarashi
Honami Akechi
Masayuki Ikeda
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses

Tomoko Kobayashi
Junko S. Takeuchi
Yoshio Koyanagi
ResearchOpen Access02 Jul 2014
Scientific Reports

Volume: 4, P: 1-8
A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses

Eri Yamada
Rokusuke Yoshikawa
Kei Sato
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Pyramiding of multiple strong-culm genes originating from indica and tropical japonica to the temperate japonica rice

Taiichiro Ookawa
Tomohiro Nomura
Takashi Motobayashi
ResearchOpen Access13 Sept 2022
Scientific Reports

Volume: 12, P: 1-11
Deep-intronic variant of fukutin is the most prevalent point mutation of Fukuyama congenital muscular dystrophy in Japan

Kazuhiro Kobayashi
Reiko Kato
Tatsushi Toda
Research06 Jul 2017
Journal of Human Genetics

Volume: 62, P: 945-948

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