The hypothesis that brain cancer might arise from a small population of cancer stem cells has received much attention in recent years. In this Viewpoint, however, Fomchenko and Holland argue that brain tumorigenesis might be more complex than this. They suggest that many of the stem-like cells found in brain tumors might have been recruited from surrounding tissues, and they discuss the implications for cancer therapy.
- Elena I Fomchenko
- Eric C Holland
