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Showing 1–10 of 10 results
Advanced filters: Author: Eric V. Anslyn Clear advanced filters

  • ortho-Aminomethylphenylboronic acids are routinely used in sensors for carbohydrates, but the function of the o-aminomethyl group in enhancing binding affinity and modulating the emission of appended fluorophores has been the matter of some debate. This Review presents a unified picture of the structural features, mechanisms of sugar complexation and photophysics of these kinds of sensors.

    • Xiaolong Sun
    • Brette M. Chapin
    • Eric V. Anslyn
    Reviews
    Nature Chemistry
    Volume: 11, P: 768-778

  • Ribosomes have evolved to polymerize L-α-amino acids into proteins comprising a peptide backbone. Here, a pyridazinone backbone is formed using ribosomes in vitro, producing a variety of sequence-defined alternating block-copolymers.

    • Joongoo Lee
    • Jaime N. Coronado
    • Michael C. Jewett
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • The reversible covalent binding of mono-alcohols with high affinity is challenging because of their poor nucleophilicity. A multi-component assembly has now been used to achieve reversible binding of secondary alcohols through iminium activation and product stabilization. Moreover, such assemblies can be used to determine alcohol chirality and enantiomeric excess.

    • Lei You
    • Jeffrey S. Berman
    • Eric V. Anslyn
    Research
    Nature Chemistry
    Volume: 3, P: 943-948

  • Despite advances in peptide synthesis techniques, explicit control over the quaternary structure of synthetic peptides has remained elusive. Now, the dynamic covalent chemistry of hydrazide- and aldehyde-containing peptides has now been shown to enable the formation of unique quaternary structures with topological diversity. Using this method, oligomers were assembled into complex structures showing dramatic enhancements of antimicrobial effectiveness versus Staphylococcus Aureus.

    • James F. Reuther
    • Justine L. Dees
    • Eric V. Anslyn
    Research
    Nature Chemistry
    Volume: 10, P: 45-50

  • Logic-based computation operates widely with discrete molecules of up to nanometric sizes, but artificial molecule-based meso-scale systems which intrinsically perform logic operations are rare. Here, the authors show that self-assembled systems consisting of cyclophaneoctacarboxylates and a cationic surfactant can perform such functions.

    • Ze-Qing Chen
    • Brian Daly
    • A. Prasanna de Silva
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7

  • It has now been shown that amines and thiols can be tethered together through a Meldrum's acid-derived conjugate acceptor for applications ranging from dynamic combinatorial chemistry to biochemistry to polymer chemistry. Furthering the utility of this chemistry, the ability to then chemically ‘declick' back to the unaltered amine and thiol components is also demonstrated.

    • Katharine L. Diehl
    • Igor V. Kolesnichenko
    • Eric V. Anslyn
    Research
    Nature Chemistry
    Volume: 8, P: 968-973

  • Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of Flexizyme-mediated tRNA acylation that more effectively predict the incorporation of new monomers into peptides.

    • Joongoo Lee
    • Kenneth E. Schwieter
    • Michael C. Jewett
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult to target pharmacologically. Here, the authors identify a small molecule inhibitor that binds covalently to the D-recruitment site of ERK and induces cell death and reduces tumour growth in mice.

    • Tamer S. Kaoud
    • William H. Johnson
    • Kevin N. Dalby
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • This Perspective describes new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell proteomics.

    • Javier Antonio Alfaro
    • Peggy Bohländer
    • Chirlmin Joo
    Reviews
    Nature Methods
    Volume: 18, P: 604-617