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Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Grosjean et al. present a network-aware, self-supervised learning approach for screening neuronal activity dynamics. They demonstrate its applicability across a range of neural interventions.

Parker Grosjean
Kaivalya Shevade
Martin Kampmann
Research17 Dec 2025
Nature Machine Intelligence

Volume: 7, P: 2009-2025
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

Leng et al. establish CRISPRi screens in astrocytes to dissect pathways controlling inflammatory reactivity. They uncover two distinct inflammatory reactive signatures that are inversely regulated by STAT3 and validate that these exist in human disease.

Kun Leng
Indigo V. L. Rose
Martin Kampmann
Research27 Oct 2022
Nature Neuroscience

Volume: 25, P: 1528-1542
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma

Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging.

Stephen T. Magill
Harish N. Vasudevan
David R. Raleigh
ResearchOpen Access23 Sept 2020
Nature Communications

Volume: 11, P: 1-15
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

A new spatial transcriptomic approach reveals astrocyte heterogeneity across layers of the mammalian cerebral cortex. Astrocytes diversify into superficial-, mid- and deep-layer subtypes distinct from neuronal laminae, yet instructed by neuronal cues.

Omer Ali Bayraktar
Theresa Bartels
David H. Rowitch
Research16 Mar 2020
Nature Neuroscience

Volume: 23, P: 500-509
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.

Jiasheng Zhang
Dmitry Velmeshev
Eric J. Huang
Research31 Aug 2020
Nature

Volume: 588, P: 459-465
Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent

Specific Schwann cell-axon interactions control the initiation of myelination in the peripheral nervous system. Here the authors show that the tumour suppressor protein Lkb1 is asymmetrically localized to the Schwann cell-axon interface and co-localizes with the polarity protein Par-3 to establish the initiation of myelination.

Yun-An A. Shen
Yan Chen
Q. Richard Lu
Research26 Sept 2014
Nature Communications

Volume: 5, P: 1-11
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

Populations of astrocytes in the spinal cord are shown to express region-specific genes, with ventral astrocyte-encoded Sema3a necessary for proper motor neuron circuit organization and typical sensory afferent projection patterns; these findings suggest that astrocytes provide a positional cue for maintaining proper circuit formation and refinement.

Anna V. Molofsky
Kevin W. Kelley
David H. Rowitch
Research28 Apr 2014
Nature

Volume: 509, P: 189-194
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin

The authors present a circuit tracing method, Trans-Seq, which determines the targets of a given neuron type through anterograde tracing combined with single-cell RNA sequencing. Applying Trans-Seq to retinotectal synapses, the authors find a selective connection assembled by Nephronectin.

Nicole Y. Tsai
Fei Wang
Xin Duan
Research06 May 2022
Nature Neuroscience

Volume: 25, P: 659-674

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