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Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda

Whole-genome sequencing of polioviruses in Uganda following nOPV2 use showed high genetic stability and no sustained transmission, even though a rare double recombinant strain regained virulence, but did not spread due to high vaccination coverage.

Phionah Tushabe
Manasi Majumdar
Josephine Bwogi
ResearchOpen Access19 Jan 2026
Nature Microbiology

Volume: 11, P: 406-414
Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study

Prospective validation in the Democratic Republic of the Congo shows that implementation of nested polymerase chain reaction and nanopore sequencing is feasible in a national poliovirus laboratory

Alexander G. Shaw
Tresor Kabeya Mampuela
Placide Mbala-Kingebeni
ResearchOpen Access17 Aug 2023
Nature Microbiology

Volume: 8, P: 1634-1640
Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization

Jennifer L. Konopka-Anstadt
Ray Campagnoli
Cara C. Burns
ResearchOpen Access20 Mar 2020
npj Vaccines

Volume: 5, P: 1-9

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