Metastases are known to preferentially spread through the lymphatic vessels. Here the authors uncover a self-reinforcing paracrine loop between breast cancer cells and lymphatic endothelial cells, which promotes seeding of cancer cells and angiogenesis in pre-metastatic niches but can be effectively blocked by repurposed therapeutic agents.
- Esak Lee
- Elana J. Fertig
- Aleksander S. Popel
