Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature Chemical Biology (2)
Nature Genetics (1)
Communications Biology (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (4)

Subject Check one or more subjects to show results from those subjects only.

Drug discovery
Genetics

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–4 of 4 results

Advanced filters: Author: Ethan Perlstein Clear advanced filters

CHK1 inhibition rescues abnormal glycogen buildup in a Caenorhabditis elegans model for glycogen storage disease III

Patient-specific C. elegans model of Glycogen Storage Disease Type III shows significant glycogen accumulation. Through computational and drug screening approaches, CHK1 was identified as a potential modifier of disease-relevant phenotypes.

Hiba Daghar
Blake Pyman
J. Alex Parker
ResearchOpen Access23 Jan 2026
Communications Biology

P: 1-12
Genetic basis of individual differences in the response to small-molecule drugs in yeast

Ethan O Perlstein
Douglas M Ruderfer
Leonid Kruglyak
Research04 Mar 2007
Nature Genetics

Volume: 39, P: 496-502
Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway

Rebecca A Butcher
Bhupinder S Bhullar
Stuart L Schreiber
Research15 Jan 2006
Nature Chemical Biology

Volume: 2, P: 103-109
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

Sovan Sarkar
Ethan O Perlstein
David C Rubinsztein
Research07 May 2007
Nature Chemical Biology

Volume: 3, P: 331-338