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The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells

HMGCR is upregulated by E2F1, driving ferroptosis resistance by reducing oxidative damage triggered by T cell-based therapy. Notably, targeting HMGCR restores ferroptosis sensitivity in immune-refractory tumors, enhancing response to PD-1 blockade as well as adoptive T cell transfer therapy.

Sung Wook Son
Hyo-Jung Lee
Kwon-Ho Song
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids

Challenges in reproducibility and large-scale expansion limit the current applicability of human intestinal organoids. Here, the authors present a feeder-free, chemically-defined culture method for enrichment of intestinal stem cells isolated from 3D human intestinal organoids.

Ohman Kwon
Hana Lee
Mi-Young Son
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-14
Publisher Correction: 2D MoS₂ as an efficient protective layer for lithium metal anodes in high-performance Li–S batteries

Eunho Cha
Mumukshu D. Patel
Wonbong Choi
Amendments and Corrections04 Apr 2018
Nature Nanotechnology

Volume: 13, P: 521
HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

Nanog can confer resistance to cancer immunotherapy by promoting AKT activity. Here, the authors demonstrate that HSP90A is a Nanog target that stabilizes the AKT coactivator TCL1, thereby activating AKT, and that HSP90A inhibition can enhance the anti-tumor efficacy of adoptive T cell transfer and checkpoint blockade.

Kwon-Ho Song
Se Jin Oh
Tae Woo Kim
ResearchOpen Access28 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes

Translationally controlled tumor protein (TCTP) regulates several cellular processes, including apoptosis, and is overexpressed in several cancer types. Here, the authors report that high levels of TCTP are associated with poor response to anti-PD-L1 and that TCTP targeting increases the efficacy of T cell-mediated anti-tumor therapy.

Hyo-Jung Lee
Kwon-Ho Song
Tae Woo Kim
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Ubiquitous Graphene Electronics on Scotch Tape

Yoonyoung Chung
Hyun Ho Kim
Kilwon Cho
ResearchOpen Access29 Jul 2015
Scientific Reports

Volume: 5, P: 1-8
Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis

Tobias Kind
Eunho Cho
Jayoung Kim
ResearchOpen Access15 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Ultraflexible and transparent electroluminescent skin for real-time and super-resolution imaging of pressure distribution

Electronic skin that spatially maps pressure distribution through imaging shows limited performance despite improvements to data acquisition. Here, the authors report ultraflexible, transparent electroluminescent skin capable of high-resolution imaging of pressure distribution over 3D surfaces.

Byeongmoon Lee
Ji-Young Oh
Yongtaek Hong
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-11
2D MoS₂ as an efficient protective layer for lithium metal anodes in high-performance Li–S batteries

An ~10-nm-thick MoS₂ layer stabilizes lithium metal anodes and the composite can be used in full-cell Li–S batteries with enhanced performances.

Eunho Cha
Mumukshu D. Patel
Wonbong Choi
Research12 Feb 2018
Nature Nanotechnology

Volume: 13, P: 337-344
NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59

Sung Wook Son
Eunho Cho
Tae Woo Kim
ResearchOpen Access23 May 2022
Scientific Reports

Volume: 12, P: 1-10
TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing

Min Kyu Son
Hyo-Jung Lee
Tae Woo Kim
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Author Correction: Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A

Muhammad Shahid
Nicole Gull
Jayoung Kim
Amendments and CorrectionsOpen Access16 Apr 2018
Scientific Reports

Volume: 8, P: 1
Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis

Muhammad Shahid
Min Young Lee
Jayoung Kim
ResearchOpen Access18 Jul 2018
Scientific Reports

Volume: 8, P: 1-12
Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A

Muhammad Shahid
Nicole Gull
Jayoung Kim
ResearchOpen Access14 Mar 2018
Scientific Reports

Volume: 8, P: 1-11

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