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Showing 1–14 of 14 results
Advanced filters: Author: Evan Ellison Clear advanced filters

  • Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

    • A. Cole Burton
    • Christopher Beirne
    • Roland Kays
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 8, P: 924-935

  • Natural isolates of Caenorhabditis elegans nematodes differ in their sensitivity to the anti-exploratory pheromone icas#9, yielding two distinct foraging strategies that possess different survival advantages depending on environmental conditions such as food distribution.

    • Joshua S. Greene
    • Maximillian Brown
    • Cornelia I. Bargmann
    Research
    Nature
    Volume: 539, P: 254-258

  • Live growth and Raman microscopy of Anabaena sp. ATCC 33047 reveals calcite precipitation induced by mechanical stress and heterocyst-seed crystal contact, thereby advancing our understanding of how these cells impact their microenvironment.

    • Christian M. Brininger
    • Jian Wei Tay
    • Jeffrey C. Cameron
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-8

  • p53 is an important tumour suppressor gene. Two papers now show in a Kras-driven lung cancer model that p53-mediated tumour suppression is only engaged late during tumour progression, when the Kras oncogenic signal reaches a threshold sufficient to activate the ARF–p53 pathway. Therefore, p53 re-expression in p53-deficient lung tumours does not restrict early stages of tumorigenesis, but induces tumour regression of more aggressive tumours.

    • Melissa R. Junttila
    • Anthony N. Karnezis
    • Carla P. Martins
    Research
    Nature
    Volume: 468, P: 567-571

  • A combination of PCR stitching with next-generation sequencing results in Stitch-seq, a massively parallel method for interactome mapping. The approach is applied to human protein-protein interactions assayed in yeast two-hybrid screens.

    • Haiyuan Yu
    • Leah Tardivo
    • Marc Vidal
    Research
    Nature Methods
    Volume: 8, P: 478-480

  • An efficient and multiplexed in planta gene editing approach is developed by infecting Cas9 transgenic plants with an RNA virus that expresses single guide RNAs carrying sequences that confer cell-to-cell mobility.

    • Evan E. Ellison
    • Ugrappa Nagalakshmi
    • Daniel F. Voytas
    Research
    Nature Plants
    Volume: 6, P: 620-624

  • p53 is an evolutionarily ancient coordinator of metazoan stress responses and its role in tumour suppression is likely to be a relatively recent adaptation. This Review discusses how such evolutionary retooling of this venerable transcription factor entails compromises that restrict its efficacy as a tumour suppressor.

    • Melissa R. Junttila
    • Gerard I. Evan
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 821-829

  • Exome sequencing has found an excess of de novo mutations in the ∼4,000 most intolerant genes in patients with two classical epileptic encephalopathies (infantile spasms and Lennox–Gastaut syndrome); among them are multiple de novo mutations in GABRB3 and ALG13.

    • Andrew S. Allen
    • Samuel F. Berkovic
    • Melodie R. Winawer
    Research
    Nature
    Volume: 501, P: 217-221