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Showing 1–4 of 4 results
Advanced filters: Author: Evi Masschelein Clear advanced filters
  • Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify cellular and molecular changes in the muscle microenvironment during PAD, focusing on endothelial cell–macrophage interactions.

    • Guillermo Turiel
    • Thibaut Desgeorges
    • Katrien De Bock
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1221-1240
  • mTORC1 is an important regulator of muscle mass. Here, the authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner. PHD1 prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucine.

    • Gommaar D’Hulst
    • Inés Soro-Arnaiz
    • Katrien De Bock
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

    • Marnix H Medema
    • Renzo Kottmann
    • Frank Oliver Glöckner
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 11, P: 625-631