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Showing 1–3 of 3 results
Advanced filters: Author: Evi X. Stavrou Clear advanced filters

  • While neutrophils are the first line of defence against infections and inflammation, their unrestricted recruitment and constant activation might result in prolonged inflammation and sharpening of specific pathological conditions. Here the authors develop a strategy to specifically target activated, pro-inflammatory neutrophils and neutrophil–platelet complexes to deliver therapeutics in the context of a murine model of venous thrombosis.

    • Michelle A. Cruz
    • Dillon Bohinc
    • Evi X. Stavrou
    Research
    Nature Nanotechnology
    Volume: 17, P: 1004-1014

  • Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.

    • Marco Heestermans
    • Clément Naudin
    • Thomas Renné
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models without an increased bleeding risk, the primary complication of all currently used anticoagulants.

    • Linda Labberton
    • Ellinor Kenne
    • Thomas Renné
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14