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Engineered alcohol oxidases catalyse transesterification in aqueous media without competing hydrolysis

Transesterification reactions are essential in organic chemistry, however, performing these reactions in aqueous media is challenging due to the competing hydrolysis reaction. Here, the authors report a mutant of alcohol oxidase from Phanerochaete chrysosporium (PcAOx-VPN) that exhibits no hydrolytic activity, enabling transesterification reactions in water.

Bin Wu
Yunjian Ma
Yonghua Wang
ResearchOpen Access30 Jan 2026
Nature Communications

P: 1-9
Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism

S Stöckler
U Holzbach
J Frahm
Research01 Sept 1994
Pediatric Research

Volume: 36, P: 409-413
Effects of Riboflavin on Gunn Rats under Phototherapy

L Ballowitz
A Bunjamin
D Wirjadi
Research01 Dec 1979
Pediatric Research

Volume: 13, P: 1307-1315
Determination of Oligoclonal Gammaglobulin in the CSF of Children with Subacute and Chronic CNS-Infections by Quantitative Agarosegel Electrophoresis: 44

H Siemes
M Siegert
F Hanefeld
Research01 Feb 1980
Pediatric Research

Volume: 14, P: 172-173
73: Increased kernicterus rate in homozygous Gunn rats after application of different antibiotics

F Hanefeld
L Ballowitz
H Helge
Research01 Oct 1976
Pediatric Research

Volume: 10, P: 883
MECP2 mutations in Danish patients with Rett syndrome: High frequency of mutations but no consistent correlations with clinical severity or with the X chromosome inactivation pattern

Jytte Bieber Nielsen
Karen Friis Henriksen
Niels Tommerup
Research11 Apr 2001
European Journal of Human Genetics

Volume: 9, P: 178-184
Giant axonal neuropathy locus refinement to a < 590 kb critical interval

Laurent Cavalier
Christiane BenHamida
Fayçal Hentati
Research24 Jul 2000
European Journal of Human Genetics

Volume: 8, P: 527-534
71 NERVE GROWTH FACTOR - AN ENDOCRINE ROLE?

U Stephani
A Sutter
A Zimmermann
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 272
Mutations in the C-terminus of CDKL5: proceed with caution

Bertrand Diebold
Chloé Delépine
Thierry Bienvenu
Research12 Jun 2013
European Journal of Human Genetics

Volume: 22, P: 270-272
THE CSF-PROTEIN PATTERNS IN CHILDREN WITH ACUTE CEREBELLAR ATAXIA AND WITH MEDULLOBLASTOMAS

H Siemes
M Siegert
F Hanefeld
Research01 Dec 1980
Pediatric Research

Volume: 14, P: 1423
Functional structure and strenght of the growth apparatus in normal and in uremic rats: 38

B Krempien
J Luckey
Research01 Feb 1980
Pediatric Research

Volume: 14, P: 172
Early onset seizures and Rett-like features associated with mutations in CDKL5

Julie C Evans
Hayley L Archer
Angus J Clarke
Research13 Jul 2005
European Journal of Human Genetics

Volume: 13, P: 1113-1120
α-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-κB transcriptional activity

Hye-Soon Kim
Hye-Jin Kim
In-Kyu Lee
ResearchOpen Access01 Feb 2007
Experimental & Molecular Medicine

Volume: 39, P: 106-113
Riboflavin and phototherapy in Gunn rats

L Ballowitz
A Bunjamin
D Wirjadi
Research01 Jan 1979
Pediatric Research

Volume: 13, P: 74
78: Inhibition of normal male sex differentiation in male offspring of rabbits actively immunized against testosterone (T) before pregnancy

F Bidlingmaier
D Knorr
F Neumann
Research01 Oct 1976
Pediatric Research

Volume: 10, P: 883
81: Impaired interauterine gonadotropin secretion as an etiological component of cryptorchidism

F Hadziselimovic
B Herzog
J Girard
Research01 Oct 1976
Pediatric Research

Volume: 10, P: 883
70 NUTRITION-INDUCED CHANGES IN INSULIN-LIKE GROWTH FACTORS (IGF'S) AND BINDING PROTEINS IN NEONATAL RATS

A F Philipps
K Drackenberg
V Sara
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 272
1139 PARATHYROID (PTH) AND ANTIDIURETIC HORMONE (ADH) IN REYE-JOHNSON SYNDROME (RJS)

Ellen S Kano
Genaro M A Palmieri
John F Griffith
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 632
The Response To Hypoxia is Affected By Creatine in the Central Respiratory Network of Mammals 251

B Wilken
J M Ramirez
F Hanefeld
Research01 Sept 1996
Pediatric Research

Volume: 40, P: 557
Stable-Isotope Dilution Analysis of D- and L-2-Hydroxyglutaric Acid: Application to the Detection and Prenatal Diagnosis of D- and L-2-Hydroxyglutaric Acidemias

K M Gibson
H J Ten Brink
C Jakobs
Research01 Sept 1993
Pediatric Research

Volume: 34, P: 277-280
14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements

Lila Allou
Laetitia Lambert
Christophe Philippe
Research27 Jun 2012
European Journal of Human Genetics

Volume: 20, P: 1216-1223
Effects of dipeptidyl peptidase-4 inhibitors on beta-cell function and insulin resistance in type 2 diabetes: meta-analysis of randomized controlled trials

Xiafei Lyu
Xiaolin Zhu
Xingwu Ran
ResearchOpen Access21 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Analysis of Hungarian patients with Rett syndrome phenotype for MECP2, CDKL5 and FOXG1 gene mutations

Kinga Hadzsiev
Noemi Polgar
Bela Melegh
Research16 Dec 2010
Journal of Human Genetics

Volume: 56, P: 183-187
Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential Hypertension

Futoshi Anan
Takayuki Masaki
Hironobu Yoshimatsu
Research01 Aug 2008
Hypertension Research

Volume: 31, P: 1565-1571
Early Reduction of Total N-Acetyl-Aspartate-Compounds in Patients With Classical Vanishing White Matter Disease. A Long-Term Follow-Up MRS Study

Steffi F Dreha-Kulaczewski
Peter Dechent
Folker A Hanefeld
Research01 Apr 2008
Pediatric Research

Volume: 63, P: 444-449
Pattern of 24-Hour Ambulatory Blood Pressure Monitoring in Type 2 Diabetic Patients with Cardiovascular Dysautonomy

Claudia R L Cardoso
Nathalie C Leite
Gil F Salles
Research01 May 2008
Hypertension Research

Volume: 31, P: 865-872
Evaluation of bilirubin cytotoxicity and phototherapy in baby Gnnn rats by histochemical enzyme marking of Purkinje cells

F Hanefeld
L Ballowitz
H Helge
Research01 Nov 1974
Pediatric Research

Volume: 8, P: 912
CONGENITAL MYOPATHY IN LOWE' SYNDROME

F Hanefeld
T H Lennert
G Stoltenburg
Research01 Dec 1980
Pediatric Research

Volume: 14, P: 1427
Creatine Protects the Central Respiratory Network of Mammals under Anoxic Conditions

B Wilken
J M Ramirez
F Hanefeld
Research01 Jan 1998
Pediatric Research

Volume: 43, P: 8-14
The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

Christian von Loeffelholz
Lidia Castagneto Gissey
Andreas L. Birkenfeld
Research24 May 2018
International Journal of Obesity

Volume: 42, P: 2057-2061
Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria

Garcia-Senosiain et al developed an in vitro opsonic phagocytosis (OP) assay using peripheral blood leukocytes that enabled quantification of the contribution of each phagocytic cell type in the OP of Plasmodium falciparum blood-stage merozoites, which have been associated with malaria protection. Using patient samples from Ghana and India, they demonstrate that peripheral blood neutrophils are the main phagocytes of P. falciparum blood-stage merozoites

Asier Garcia-Senosiain
Ikhlaq Hussain Kana
Michael Theisen
ResearchOpen Access19 Aug 2021
Communications Biology

Volume: 4, P: 1-10
Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome

W Krone
M Hanefeld
W P Dole
Research08 Apr 2010
Journal of Human Hypertension

Volume: 25, P: 186-195
Waist-to-height ratio and metabolic phenotype compared to the Matsuda index for the prediction of insulin resistance

Katharina Lechner
Benjamin Lechner
Helene von Bibra
ResearchOpen Access15 Apr 2021
Scientific Reports

Volume: 11, P: 1-10
Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study

H Toplak
A Hamann
M Fitchet
Research16 May 2006
International Journal of Obesity

Volume: 31, P: 138-146
A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects

J Wilding
L Van Gaal
M Fitchet
Research21 Sept 2004
International Journal of Obesity

Volume: 28, P: 1399-1410
Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs

M A Daniels
C Kan
A L Birkenfeld
Reviews19 Jul 2016
The Pharmacogenomics Journal

Volume: 16, P: 399-410

Search

Engineered alcohol oxidases catalyse transesterification in aqueous media without competing hydrolysis

Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism

Effects of Riboflavin on Gunn Rats under Phototherapy

Determination of Oligoclonal Gammaglobulin in the CSF of Children with Subacute and Chronic CNS-Infections by Quantitative Agarosegel Electrophoresis: 44

73: Increased kernicterus rate in homozygous Gunn rats after application of different antibiotics

MECP2 mutations in Danish patients with Rett syndrome: High frequency of mutations but no consistent correlations with clinical severity or with the X chromosome inactivation pattern

Giant axonal neuropathy locus refinement to a < 590 kb critical interval

71 NERVE GROWTH FACTOR - AN ENDOCRINE ROLE?

Mutations in the C-terminus of CDKL5: proceed with caution

THE CSF-PROTEIN PATTERNS IN CHILDREN WITH ACUTE CEREBELLAR ATAXIA AND WITH MEDULLOBLASTOMAS

Functional structure and strenght of the growth apparatus in normal and in uremic rats: 38

Early onset seizures and Rett-like features associated with mutations in CDKL5

α-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-κB transcriptional activity

Riboflavin and phototherapy in Gunn rats

78: Inhibition of normal male sex differentiation in male offspring of rabbits actively immunized against testosterone (T) before pregnancy

81: Impaired interauterine gonadotropin secretion as an etiological component of cryptorchidism

70 NUTRITION-INDUCED CHANGES IN INSULIN-LIKE GROWTH FACTORS (IGF'S) AND BINDING PROTEINS IN NEONATAL RATS

1139 PARATHYROID (PTH) AND ANTIDIURETIC HORMONE (ADH) IN REYE-JOHNSON SYNDROME (RJS)

The Response To Hypoxia is Affected By Creatine in the Central Respiratory Network of Mammals 251

Stable-Isotope Dilution Analysis of D- and L-2-Hydroxyglutaric Acid: Application to the Detection and Prenatal Diagnosis of D- and L-2-Hydroxyglutaric Acidemias

14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements

Effects of dipeptidyl peptidase-4 inhibitors on beta-cell function and insulin resistance in type 2 diabetes: meta-analysis of randomized controlled trials

Analysis of Hungarian patients with Rett syndrome phenotype for MECP2, CDKL5 and FOXG1 gene mutations

Postchallenge Plasma Glucose and Glycemic Spikes Are Associated with Pulse Pressure in Patients with Impaired Glucose Tolerance and Essential Hypertension

Early Reduction of Total N-Acetyl-Aspartate-Compounds in Patients With Classical Vanishing White Matter Disease. A Long-Term Follow-Up MRS Study

Pattern of 24-Hour Ambulatory Blood Pressure Monitoring in Type 2 Diabetic Patients with Cardiovascular Dysautonomy

Evaluation of bilirubin cytotoxicity and phototherapy in baby Gnnn rats by histochemical enzyme marking of Purkinje cells

CONGENITAL MYOPATHY IN LOWE' SYNDROME

Creatine Protects the Central Respiratory Network of Mammals under Anoxic Conditions

The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria

Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome

Waist-to-height ratio and metabolic phenotype compared to the Matsuda index for the prediction of insulin resistance

Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study

A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects

Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs

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