Inflammation has a key role in the pathogenesis and progression of diabetic nephropathy; however, the pathways, ligands and receptors involved in this condition are complex and only partially understood. The authors of this Review discuss the molecular networks that are implicated in the development of diabetic nephropathy and describe how these pathways function in health and disease, as well as their importance in the identification and development of potential therapeutics.
- Juan F. Navarro-González
- Carmen Mora-Fernández
- Javier García-Pérez