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Advanced filters: Author: Fabian Morales-Polanco Clear advanced filters

NAC controls nascent chain fate through tunnel sensing and chaperone action

Jae Ho Lee
Laurenz Rabl
Judith Frydman
Research22 Dec 2025
Nature

P: 1-3
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT

Sontag et al. show that nuclear misfolded proteins and juxtanuclear cytoplasmic misfolded proteins converge to opposite sides of the nuclear envelope, proximal to nuclear–vacuolar junctions for ESCRT-dependent egress to the vacuole.

Emily M. Sontag
Fabián Morales-Polanco
Judith Frydman
Research20 Apr 2023
Nature Cell Biology

Volume: 25, P: 699-713
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis

Ageing alters the kinetics of translation elongation in both Caenorhabditis elegans and Saccharomyces cerevisiae.

Kevin C. Stein
Fabián Morales-Polanco
Judith Frydman
Research19 Jan 2022
Nature

Volume: 601, P: 637-642

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NAC controls nascent chain fate through tunnel sensing and chaperone action

Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT

Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis

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