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Drainage of two surface lakes on Greenland’s fastest ice stream caused a pulse of faster flow to propagate downstream and triggered a long calving episode, suggesting the entire stream is strongly coupled, according to geophysical field observations.

Two high-redshift post-starburst galaxies are in the process of quenching, although their quasars remain active, indicating the complex co-evolution between black hole activity and star formation.

An adjuvanted SARS-CoV-2 spike-ferritin nanoparticle vaccine can elicit antibodies with relatively broad sarbecovirus activity in non-human primates. Here, the authors isolate and structurally characterize several monoclonal antibodies providing insights into the targeted epitopes and broad reactivity.

Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Iceberg calving can act as a submarine melt amplifier through excitation of transient internal waves.

The discovery of a distant blazar J0410−0139 at z = 7 suggests that many similar sources existed in the early Universe, supporting the hypothesis that the rapid growth of black holes is driven by jet-enhanced or obscured accretion.

Krebs and colleagues identify multiple mAbs that recognize either the RBD or the NTD of SARS-CoV-2 spike protein that have potent cross-neutralizing activities against variants of concern. Combinatorial mAb cocktails have complementary effects on viral neutralization and Fc effector functions and can protect against SARS-CoV-2 escape mutants.

Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

NKG7 is a molecule well associated with NK cells but of unknown function. Engwerda and colleagues demonstrate that NKG7 is also associated with T_H1 cells and is essential for type I and cytotoxic responses.

The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling.

The enzymatic breakdown of the lipid sphingomyelin is associated with various infectious diseases. Here, the authors introduce trifunctional sphingomyelin derivatives for the visualisation of sphingomyelin distribution and sphingomyelinase activity in infection processes.

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Aromatic chemicals, having indispensable roles in human society, are currently produced from fossil resources. Here, the authors introduce a strategy to synthesize benzenoid aromatics from bio-based feedstock, showing the possibility of phasing out fossil-based feedstocks in aromatics production.

Using a millimetre-wave molecular line scan, a redshift has finally been determined for the extremely active star-forming galaxy HDF 850.1 in the Hubble Deep Field, which makes it younger than thought at 1.1 billion years after the Big Bang.

2D materials are being investigated for several applications in micro- and nanoelectronics, but their weak adhesion represents a critical challenge for device integration. Here, the authors propose a button shear testing method to evaluate the adhesion forces of various large-area 2D films on SiO₂ and Si₃N₄ substrates.

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Measurement of the cosmic microwave background temperature using H₂O absorption at a redshift of 6.34 is reported, the results of which were consistent with those from standard ΛCDM cosmology.

Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.

Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

The microscopic pairing mechanism in high-temperature superconductors remains debated. Here, the authors offer a new perspective on this problem by proposing that the strong pairing in Fermi-Hubbard type models relevant to cuprates is driven by a Feshbach resonance, which enhances interactions between doped holes.

Changes in lipidome profiles, as reflected by improvements in dietary fat quality from saturated to unsaturated fats, were associated with reduced cardiometabolic disease risk, and high-risk populations with unhealthy lipidome profiles would most benefit from an olive oil-rich Mediterranean diet.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

The mechanism underlying packaging of the 8 segments of the influenza virus genome into virions is not well understood. Here, the authors use a multiplexed FISH assay to monitor the 8 segments in parallel in infected cells suggesting bundling routes during the packaging process.

A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

A method called vessel isolation and nuclei extraction for sequencing (VINE-seq) produces a molecular map of vascular and perivascular cell types in the human brain and reveals their contributions to Alzheimer’s disease risk.

Nicole Soranzo, Tim Spector, Gabi Kastenmüller and colleagues report a large-scale analysis of genetic variants influencing human blood metabolite levels. They identify genome-wide significant associations at 145 loci, providing a framework for exploring relationships between genetic variation, metabolism and complex disease.

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

While earthquakes are known to trigger landslides and initiate hazard cascades, the authors show that landslide hazard cascades can instead trigger earthquakes by increasing stresses on faults through direct loading and pore pressure diffusion.

Computational modelling and mouse genetics approaches show that multipotent progenitor cells that have the potential to populate the hepato-pancreato-biliary lineage tree persist in the pancreato-biliary organ rudiment.

The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning.

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

A significant proportion of individuals with inherited neuromuscular disease do not receive a genetic diagnosis. Here, the authors establish CCG expansions in the 5’ untranslated region of ABCD3 as a cause of oculopharyngodistal myopathy (OPDM) in individuals of European ancestry and identify increased expression of expansion-containing ABCD3 transcripts as a possible disease mechanism underlying muscle degeneration.

Single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.

The host galaxy of the quasar SDSS J114816.64?525150.3 has an infrared luminosity of 2.2 × 10¹³times that of the Sun. In the extremely luminous 'local' galaxy Arp 220, the burst of star formation is concentrated in the relatively small central region of <100 pc radius. This study reports that the star-forming gas of the host galaxy of J114816.64525150.3 is distributed over a radius of about 750 pc around the centre. The surface density of the star formation rate averaged over this region is comparable to the peak in Arp 220, although about two orders of magnitude larger in area.

Observations of the galaxy NGC 253 show that the cool molecular wind from the central starburst region limits star-formation activity and the final stellar content.

The most distant quasars known, at redshifts z ≈ 6, generally have the same properties as lower-redshift quasars, implying that although the Universe was young at z ≈ 6, such quasars are still evolved objects. One z ≈ 6 quasar was shown to have no detectable emission from hot dust, but it was not clear whether it was an outlier. Now, a second quasar without hot-dust emission has been discovered in a sample of 21 z ≈ 6 quasars. Moreover, hot-dust abundance in these quasars builds up as the central black hole grows.

Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ₆.

Analysis of human genotypes and 16S microbiome data of 18,473 individuals from 25 cohorts through a genome-wide association study, a phenome-wide association study and Mendelian randomization identifies host genetic and microbial trait associations.

Authors report that long-term intestinal tissue maintenance in naked mole rats is achieved by having an expanded pool of slow-dividing adult stem cells while a higher proportion of differentiated cells confer enhanced function and protection to the intestinal mucosa.

Aging is a key risk factor for chronic diseases of the elderly. Here the authors perform large-scale miRNA profiling of blood from individuals of a range of ages and show that common diseases alter the physiological age-related blood microRNA profile.

Images and spectroscopy obtained by the JWST from two HSC-SSP quasars show massive, compact and disc-like galaxies, indicating that the relation between black holes and their host galaxies was in place less than a billion years after the Big Bang.

Observations of local galaxy I Zw 18 imply that the dust mass in star-forming, metal-poor environments is much lower than expected, and, therefore, that the amount of dust in young galaxies of the early Universe, such as redshift-6.6 galaxy Himiko, is probably a factor of about 100 less than previously thought.