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Structural insights into the agonist selectivity of the adenosine A₃ receptor

Adenosine A₃ receptor (A₃R) plays important roles in neurons, heart, and immune cells, and is often overexpressed in tumors. Oshima et al. identify tRNA-derived i⁶A as an A₃R-selective ligand and use cryo-EM to reveal A₃R’s selectivity and activation mechanisms.

Hidetaka S. Oshima
Akiko Ogawa
Osamu Nureki
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-13
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.

Takaaki Akaike
Tomoaki Ida
Hozumi Motohashi
ResearchOpen Access27 Oct 2017
Nature Communications

Volume: 8, P: 1-15
Cdk5-dependent regulation of glucose-stimulated insulin secretion

Fan-Yan Wei
Kazuaki Nagashima
Kazuhito Tomizawa
Research11 Sept 2005
Nature Medicine

Volume: 11, P: 1104-1108
Supersulphides provide airway protection in viral and chronic lung diseases

The physiological roles of supersulphides and the enzymes that trigger their production in various airway diseases are not fully understood. Here, the authors show in animal models of viral and chronic lung diseases that supersulphide production can mitigate lung pathology and lethal effects, highlighting their protective role and potential as a therapeutic target.

Tetsuro Matsunaga
Hirohito Sano
Takaaki Akaike
ResearchOpen Access25 Jul 2023
Nature Communications

Volume: 14, P: 1-25
Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells

Sayaka Watanabe
Fan-Yan Wei
Kazuhito Tomizawa
ResearchOpen Access04 May 2016
Scientific Reports

Volume: 6, P: 1-10
Epitranscriptomics in metabolic disease

Matsumura, Wei and Sakai discuss epitranscriptomic modifications and their links to metabolic disease, how genetic and environmental factors influence epitranscriptomics, and how the epitranscriptome is linked to the epigenome.

Yoshihiro Matsumura
Fan-Yan Wei
Juro Sakai
Reviews23 Mar 2023
Nature Metabolism

Volume: 5, P: 370-384
TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA

Knockout of mitochondrial transcription elongation factor, TEFM, in cultured human cells suggests the role of this protein in maintaining the balance between mitochondrial transcription and replication.

Shigeru Matsuda
Masunari Nakayama
Takehiro Yasukawa
ResearchOpen Access08 Feb 2025
Communications Biology

Volume: 8, P: 1-13
Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation

DUS1L was identified as the human tRNA dihydrouridine writer for positions 16 and 17. DUS1L overexpression changes the amount of several D16/D17-containing tRNAs and increases total cellular translation and cell growth in glioblastoma cells.

Jin Matsuura
Shinichiro Akichika
Takeshi Chujo
ResearchOpen Access02 Oct 2024
Communications Biology

Volume: 7, P: 1-12
Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

The SARS-CoV-2 drug remdesivir is a partial agonist for urotensin 2 receptor, leading to aberrant cardiomyocyte activity in vitro.

Akiko Ogawa
Seiya Ohira
Fan-Yan Wei
ResearchOpen Access12 May 2023
Communications Biology

Volume: 6, P: 1-13
NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

A mitochondrial tRNA modification enzyme, NSUN3, is found to be essential for embryonic development in mice, with whole-body knockout causing embryonic lethality and heart-specific Nsun3 knockout leading to heart aberration in older mice.

Yoshitaka Murakami
Fan-Yan Wei
Takeshi Chujo
ResearchOpen Access22 Mar 2023
Communications Biology

Volume: 6, P: 1-12
Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset myopathy caused by the expansion of polyalanine in the PABPN1 gene. Abnormal accumulation of PABPN1 on the inner membrane of mitochondria was detected in mouse and cell models of OPMD. The localization of expanded PABPN1 in mitochondria may be associated with mitochondrial dysfunction.

Tsukasa Doki
Satoshi Yamashita
Yukio Ando
Research20 Mar 2019
Laboratory Investigation

Volume: 99, P: 1728-1740
Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats

Teruo Miyazaki
Sei-Ich Sasaki
Akira Honda
ResearchOpen Access18 Mar 2020
Scientific Reports

Volume: 10, P: 1-15
Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

Keiichiro Hayashi
Hiroyuki Michiue
Hideki Matsui
ResearchOpen Access18 Mar 2016
Scientific Reports

Volume: 6, P: 1-12

Search

Structural insights into the agonist selectivity of the adenosine A₃ receptor

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Cdk5-dependent regulation of glucose-stimulated insulin secretion

Supersulphides provide airway protection in viral and chronic lung diseases

Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells

Epitranscriptomics in metabolic disease

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA

Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation

Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy

Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats

Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

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