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Showing 1–4 of 4 results
Advanced filters: Author: Fanny Mermet-Meillon Clear advanced filters

  • In this work, fragments identified by 19F-NMR are optimized into submicromolar binders of the MITF transcription factor. These results support direct targeting of bHLH-LZ DNA binding domains and provide a foundation for the development of new melanoma therapies.

    • Deborah Castelletti
    • Jürgen Hinrichs
    • Wolfgang Jahnke
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.

    • Melusine Bleu
    • Fanny Mermet-Meillon
    • Giorgio Giacomo Galli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Using deep mutational scanning, the authors uncover the functional consequence of missense mutations in ARID1B, a subunit of the SWI/SNF chromatin remodeling complex that is frequently mutated in human Coffin–Siris syndrome and in cancer.

    • Fanny Mermet-Meillon
    • Samuele Mercan
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1018-1022

  • Cancer associated fibroblasts are known to promote the progression of cancer. Here, the authors show that two particular subsets of cancer associated fibroblasts induce metastasis but work via distinct mechanisms including, chemokine signalling and Notch signalling.

    • Floriane Pelon
    • Brigitte Bourachot
    • Fatima Mechta-Grigoriou
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20