Nature Search

Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Melinda Soeung
Xinmiao Yan
Pavlos Msaouel
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-23
Two-dimensional halide perovskite as β-ray scintillator for nuclear radiation monitoring

Efficient radiation monitoring ensures safety in nuclear power, but beta-ray scintillators should be developed for use near a highly radioactive and hot reactor. Here, the authors report a two-dimensional halide perovskite-based beta-ray scintillator with high irradiation hardness and thermotolerance.

Dejian Yu
Peng Wang
Haibo Zeng
ResearchOpen Access07 Jul 2020
Nature Communications

Volume: 11, P: 1-10
Methylmercury formation in water triggered by light-independent plastic weathering

Abiotic methylation triggered by plastic debris can occur independently of light conditions and therefore drive methylmercury formation in dark waters, according to an experimental study combined with density functional theory calculations.

Yingnan Huang
Cun Liu
Baoshan Xing
Research08 Aug 2025
Nature Geoscience

Volume: 18, P: 862-868
Iron-catalysed stereoselective NH transfer enables dynamic kinetic resolution of sulfoxides

Enantioselective NH transfer that allows concise assembly of unprotected enantioenriched amines remains a challenge. Here, the authors report an iron-catalysed stereoselective NH imidation of sulfoxide, which is integrated with photocatalytic racemisation of sulfoxide, enabling a dynamic kinetic resolution strategy for direct and asymmetric synthesis of NH-sulfoximines.

Fang-Xu Fan
Hui Xu
Fei Wang
ResearchOpen Access08 Feb 2025
Nature Communications

Volume: 16, P: 1-9
Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

MYC oncogene promotes tumourigenesis by coordinating cancer cell proliferation with metabolic adaptation to the consequent excessive oxidative stress. Here, the authors show that nudix hydrolase 1 (NUDT1) is a MYC-driven metabolic vulnerability and generate a NUDT1 protein degrader to treat preclinical MYC-associated cancer.

Minhui Ye
Yingzhe Fang
Guoliang Qing
ResearchOpen Access16 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.

Zhaoyang Li
Cen Wang
Boxun Lu
Research30 Oct 2019
Nature

Volume: 575, P: 203-209
Levistolide A overcomes P-glycoprotein-mediated drug resistance in human breast carcinoma cells

Fei Chen
Tao Wang
Ming Qian
Research01 Apr 2008
Acta Pharmacologica Sinica

Volume: 29, P: 458-464
Site-selective arene C–H amination with iron-aminyl radical

Polar and steric effects usually dictate the regioselectivity in homolytic aromatic substitution. Now a method for direct ortho-selective C–H amination of aromatics with diverse side chains as directing groups is disclosed, by which the iron catalyst coordinates both the substrate and the aminyl radical.

Chao-Rui Ma
Guan-Wang Huang
Fei Wang
Research01 Apr 2024
Nature Catalysis

Volume: 7, P: 636-645
Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial

In patients with advanced clear cell renal cell carcinoma (ccRCC), sitravatinib (tyrosine kinase inhibitor) has shown efficacy both alone and in combination with nivolumab (anti-PD-1). Here, the authors investigate triplet combination of sitravatinib with nivolumab and ipilimumab (anti-CTLA4) in patients with metastatic ccRCC and longitudinal single-cell transcriptomic analysis.

Pavlos Msaouel
Kai Yu
Jianjun Gao
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-18
The waiting time of admission to operation was associated with preoperative deep vein thrombosis in geriatric hip fracture

Wen-Si Qiang
Lu Dang
Bin-Fei Zhang
ResearchOpen Access04 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Association between ossific nucleus volume changes and postoperative avascular necrosis risk in children with developmental dysplasia of the hip

Haotian Pang
Liukun Xu
Qiang Jie
ResearchOpen Access12 Sept 2024
Scientific Reports

Volume: 14, P: 1-7
Association between triglyceride glucose body mass index and 1 year all cause mortality in stage 4 CKM syndrome patients

Wen Pan
Teng-fei Ji
Jin Wei
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-13
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin

The authors present a circuit tracing method, Trans-Seq, which determines the targets of a given neuron type through anterograde tracing combined with single-cell RNA sequencing. Applying Trans-Seq to retinotectal synapses, the authors find a selective connection assembled by Nephronectin.

Nicole Y. Tsai
Fei Wang
Xin Duan
Research06 May 2022
Nature Neuroscience

Volume: 25, P: 659-674
Understanding the trade-off and synergy effects of landscape multifunctional and its driving mechanism in rapidly urbanizing areas

Hang Zhang
Shaohua Wu
Fei Xu
ResearchOpen Access11 Jul 2025
Scientific Reports

Volume: 15, P: 1-19
Significant contribution of metastable particulate organic matter to natural formation of silver nanoparticles in soils

Silver nanoparticles are known environmental contaminants, however it is unclear whether they arise in soils through natural processes, anthropogenic processes, or both. Here Huang and colleagues offer fresh insight into the natural formation of these contaminants by soil particulate organic matter exposed to solar irradiation.

Ying-Nan Huang
Ting-Ting Qian
Dong-Mei Zhou
ResearchOpen Access21 Aug 2019
Nature Communications

Volume: 10, P: 1-8
Experimental Realization of Extreme Heat Flux Concentration with Easy-to-Make Thermal Metamaterials

Fei Chen
Dang Yuan Lei
ResearchOpen Access25 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Garry Cutting and colleagues report a genome-wide association and linkage study for loci that affect lung disease severity in cystic fibrosis. They identify two loci that influence lung function in individuals with cystic fibrosis.

Fred A Wright
Lisa J Strug
Garry R Cutting
Research22 May 2011
Nature Genetics

Volume: 43, P: 539-546
Evolutionary history of the angiosperm flora of China

A dated phylogeny and spatial distribution data for Chinese angiosperms show that eastern China has tended to act as a refugium for older taxa whereas western China has acted as a centre for their evolutionary diversification.

Li-Min Lu
Ling-Feng Mao
Zhi-Duan Chen
Research31 Jan 2018
Nature

Volume: 554, P: 234-238
Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

Jun Liu
Dan-Dan Li
Zhong Wang
ResearchOpen Access01 Sept 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-10
Mechanistic understanding of MeHg-Se antagonism in soil-rice systems: the key role of antagonism in soil

Yongjie Wang
Fei Dang
Dongmei Zhou
ResearchOpen Access18 Jan 2016
Scientific Reports

Volume: 6, P: 1-11
miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6

Fei Li
Xin-ji Li
Wei Liu
ResearchOpen Access03 Oct 2014
Experimental & Molecular Medicine

Volume: 46, P: e116
The effects of dynamic daylight-like light on the rhythm, cognition, and mood of irregular shift workers in closed environment

Jingxin Nie
Tianhang Zhou
Bo Shen
ResearchOpen Access22 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma

Hao Zhuang
Fei Wu
Yongmei Li
ResearchOpen Access25 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-14
Acoustic emission characteristics and energy evolution law of rock damage process of different pore structures under cyclic loading

Haowen Jiang
Jiandong Dang
Jian Liu
ResearchOpen Access22 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis

Ke Wang
Yixuan Wang
Ge Zhang
ResearchOpen Access19 May 2020
Cell Death & Disease

Volume: 11, P: 1-18
MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53

Yingchao Wang
Gaoxiong Wang
Jingfeng Liu
ResearchOpen Access15 Nov 2019
Oncogenesis

Volume: 8, P: 1-11
Targeted overexpression of the long noncoding RNA ODSM can regulate osteoblast function in vitro and in vivo

Yixuan Wang
Ke Wang
Ge Zhang
ResearchOpen Access18 Feb 2020
Cell Death & Disease

Volume: 11, P: 1-15
Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

Qiang Xiao
Ningning Dong
Weiqiang Lu
ResearchOpen Access29 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity

Juanjuan Wang
Chenggang Zhu
Jiaxue Wu
ResearchOpen Access10 Jul 2017
Cell Death Discovery

Volume: 3, P: 1-9
Osteoblast-targeted delivery of miR-33-5p attenuates osteopenia development induced by mechanical unloading in mice

Han Wang
Zebing Hu
Ge Zhang
ResearchOpen Access07 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-13
ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells

Xiaochun Ma
Rongfang Qiu
Qiji Liu
ResearchOpen Access25 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis

Fan Zhang
Qi-Yu Zeng
Xiao-Jian Sun
ResearchOpen Access26 Oct 2021
Cell Discovery

Volume: 7, P: 1-17
Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome

Yuanyuan Che
Jinpeng Qiu
Yanfang Jiang
ResearchOpen Access11 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season

Ming Liu
Guangming Cao
Fei Gao
ResearchOpen Access04 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Distinct microbiological signatures associated with triple negative breast cancer

Sagarika Banerjee
Zhi Wei
Erle S. Robertson
ResearchOpen Access15 Oct 2015
Scientific Reports

Volume: 5, P: 1-14
The sirtuin family in health and disease

Qi-Jun Wu
Tie-Ning Zhang
Yu-Hong Zhao
ReviewsOpen Access29 Dec 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-74
Sua5p is required for telomere recombination in Saccharomyces cerevisiae

Fei-Long Meng
Xiao-Fen Chen
Jin-Qiu Zhou
Correspondence23 Mar 2010
Cell Research

Volume: 20, P: 495-498
Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision

J-j Wang
L-l Zhang
Z-g Wang
ResearchOpen Access10 Oct 2013
Cell Death & Disease

Volume: 4, P: e853

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