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Showing 1–5 of 5 results
Advanced filters: Author: Feliks Kogan Clear advanced filters

  • Non-invasive imaging of articular cartilage has evolved markedly and can be used to monitor response to treatment and predict disease outcomes. This Review provides rheumatologists with a comprehensive update on current and emerging imaging and analysis techniques for the assessment of cartilage.

    • Ali Guermazi
    • Felix Eckstein
    • Frank W. Roemer
    Reviews
    Nature Reviews Rheumatology
    P: 1-16

  • Kejia Cai et al. describe a method to non-invasively detect glutamate (Glu) concentrations in the brain with MRI at high resolution. The approach is based on the pH-dependent chemical exchange saturation transfer (CEST) effect between the amino group of Glu and bulk water and offers advantages over proton magnetic resonance spectroscopy. Feasibility of GluCEST was demonstrated in rat brain after middle cerebral artery occlusion stroke and in a rat brain tumor model, as well as in healthy human brain at 7 Tesla.

    • Kejia Cai
    • Mohammad Haris
    • Ravinder Reddy
    Research
    Nature Medicine
    Volume: 18, P: 302-306

  • The measurement of metabolites such as creatine, which are involved in the tissue creatine kinase reaction, enable the study of the effects of energy deprivation on the heart. Haris and colleagues introduce a new magnetic resonance imaging technique that maps the distribution of creatine in the heart that does not use radiation or exogenous contrast agents and offers higher sensitivity compared to proton (1H) magnetic resonance spectroscopy methods. Feasibility is demonstrated in vivo in infarcted swine myocardium using a standard clinical MRI scanner.

    • Mohammad Haris
    • Anup Singh
    • Ravinder Reddy
    Research
    Nature Medicine
    Volume: 20, P: 209-214