Nature Search

Challenging the Bredt’s rule in an acid catalyzed cationic cyclization to get bicyclo[3.3.1]nonane derivatives

Vinyl carbocations have a long history in chemistry, but they have received less attention compared to the more common sp²-hybridized trivalent carbocations and synthetic applications of these intermediates are still limited. Herein, the authors report an unexpected formal reductive Friedel-Crafts reaction, enabled by HFIP solvent and a hydride source, that transforms alkynol derivatives via a vinyl cation cyclization into bicyclo[3.3.1]nonane derivatives.

Olaya García-Pedrero
Pilar Pardo
Félix Rodríguez
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Different distribution of pattern of 100-Å filaments in resting and locomotive leukaemia cells

HEIDY FELIX
PETER STRÄULI
Research01 Jun 1976
Nature

Volume: 261, P: 604-606
T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Interrogation of electronic health records and the B and T cell repertoires of people with PSC shows a link between Epstein–Barr virus and primary sclerosing cholangitis, an incurable autoimmune liver disease.

Hesham ElAbd
Mitchell Pesesky
Andre Franke
ResearchOpen Access11 Jun 2025
Nature Medicine

Volume: 31, P: 2306-2316
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Dietary lipids are linked to the development of inflammatory bowel diseases through unclear mechanisms. Here, the authors report that dietary polyunsaturated fatty acids trigger intestinal inflammation resembling aspects of Crohn’s disease, which is restricted by glutathione peroxidase 4 in the intestinal epithelium.

Lisa Mayr
Felix Grabherr
Timon E. Adolph
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-15
Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies

Human skin biopsies retrieved from body donors provide a viable tool for investigating acute molecular mechanisms involved in UV-mediated photo-carcinogenesis, shedding light on the phototoxic properties of the diuretic drug hydrochlorothiazide.

Mathias Hohl
Felix Götzinger
Michael Böhm
ResearchOpen Access06 May 2025
Communications Biology

Volume: 8, P: 1-13
Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial

As presented at the 2025 ASCO Annual Meeting: in a randomized controlled phase 3 trial evaluating subcutaneous administration of sasanlimab, an anti-PD-1 inhibitor, with Bacillus Calmette–Guérin induction and maintenance treatment, combination treatment significantly improved event-free survival versus standard-of-care therapy.

Neal D. Shore
Thomas B. Powles
Gary D. Steinberg
ResearchOpen Access31 May 2025
Nature Medicine

Volume: 31, P: 2806-2814
Author Correction: Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial

Neal D. Shore
Thomas B. Powles
Gary D. Steinberg
Amendments and CorrectionsOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 2815
Flexible quasi-2D perovskite solar cells with high specific power and improved stability for energy-autonomous drones

Demonstration of high performance, upscaling and integration of ultra-lightweight perovskite solar cells are still rare. Hailegnaw et al. develop 2D perovskite solar cells based on methylbenzyl ammonium iodide with improved specific power and stability, showing scalability and integration in drones.

Bekele Hailegnaw
Stepan Demchyshyn
Martin Kaltenbrunner
Research17 Apr 2024
Nature Energy

Volume: 9, P: 677-690
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kinase A (PKA)-mediated phosphorylation.

Sabine Ruegenberg
Felix A. M. C. Mayr
Martin S. Denzel
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Understanding environmental trade-offs and resource demand of direct air capture technologies through comparative life-cycle assessment

Direct air capture (DAC) technologies to remove CO₂ from the atmosphere are widely used in climate policy scenarios, but their real-world impacts are not well understood. A life-cycle assessment by Madhu et al. compares two main DAC approaches and quantifies their environmental impact and resource needs.

Kavya Madhu
Stefan Pauliuk
Felix Creutzig
Research28 Oct 2021
Nature Energy

Volume: 6, P: 1035-1044
Multivalents resulting from monobrachial homologies within a hybrid zone in Dichroplus pratensis (Acrididae): meiotic orientation and segregation

C J Bidau
Research01 Apr 1991
Heredity

Volume: 66, P: 219-232
Genetic diagnosis of Mendelian disorders via RNA sequencing

Genome sequencing alone fails to provide a genetic diagnosis for many Mendelian disorder patients. Here, the authors utilize RNA sequencing to complement genotyping of patients with a rare mitochondrial disease by detecting aberrant RNA expression, splicing and allele-specific expression.

Laura S. Kremer
Daniel M. Bader
Holger Prokisch
ResearchOpen Access12 Jun 2017
Nature Communications

Volume: 8, P: 1-11
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Many individual genetic risk loci associate with multiple diseases, but the molecular basis of these loci often remains unclear. Here, the authors provide a framework to reveal the genetic cross-disease associations at the PROCR vascular disease locus.

David Stacey
Lingyan Chen
Dirk S. Paul
ResearchOpen Access09 Mar 2022
Nature Communications

Volume: 13, P: 1-15
Integrating hybrid zone analyses in species delimitation: lessons from two anuran radiations of the Western Mediterranean

Christophe Dufresnes
Manon Pribille
Iñigo Martínez-Solano
Research20 Jan 2020
Heredity

Volume: 124, P: 423-438
Emergence of mesoscale quantum phase transitions in a ferromagnet

LiHoF₄, a dipolar Ising ferromagnet, is investigated near its transverse-field quantum critical point, showing that well-defined mesoscale quantum phase transitions arise when tilting the magnetic field away from the hard axis.

Andreas Wendl
Heike Eisenlohr
Christian Pfleiderer
Research31 Aug 2022
Nature

Volume: 609, P: 65-70
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.

Rajasekharan Somasundaram
Gao Zhang
Stephan N. Wagner
ResearchOpen Access19 Sept 2017
Nature Communications

Volume: 8, P: 1-16
AUGUR, a flexible and efficient optimization algorithm for identification of optimal adsorption sites

Ioannis Kouroudis
Poonam
Alessio Gagliardi
ResearchOpen Access17 May 2025
npj Computational Materials

Volume: 11, P: 1-13
EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

EASI-tag, a new type of isobaric labeling reagents, enables multiplexed and highly accurate proteome quantification by mass spectrometry.

Sebastian Virreira Winter
Florian Meier
Felix Meissner
Research18 Jun 2018
Nature Methods

Volume: 15, P: 527-530
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation

Julian Schwärzler
Lisa Mayr
Timon E. Adolph
Research14 Jan 2022
International Journal of Obesity

Volume: 46, P: 951-959
Active learning graph neural networks for partial charge prediction of metal-organic frameworks via dropout Monte Carlo

Stephan Thaler
Felix Mayr
Julija Zavadlav
ResearchOpen Access03 May 2024
npj Computational Materials

Volume: 10, P: 1-10
Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder

Theresa Brunet
Kirsty McWalter
Matias Wagner
ResearchOpen Access11 Nov 2020
Genetics in Medicine

Volume: 23, P: 384-395
The metabolic nature of inflammatory bowel diseases

Experimental and clinical evidence supports a role of metabolic perturbation in the development of gut inflammation in inflammatory bowel disease (IBD). This Review discusses the role of diet and metabolic inflammation in IBD, outlining key concepts and highlighting the links between metabolism and inflammation in IBD.

Timon E. Adolph
Moritz Meyer
Herbert Tilg
Reviews29 Jul 2022
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 753-767
Social network architecture of human immune cells unveiled by quantitative proteomics

Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in detail the ‘social network’ of human immune cells and throw light on previously unknown cell connectivities.

Jan C Rieckmann
Roger Geiger
Felix Meissner
Research06 Mar 2017
Nature Immunology

Volume: 18, P: 583-593
Defining clinical subgroups and genotype–phenotype correlations in NBAS-associated disease across 110 patients

Christian Staufner
Bianca Peters
Dominic Lenz
Research25 Nov 2019
Genetics in Medicine

Volume: 22, P: 610-621
Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity

Romana R. Gerner
Sophie Macheiner
David Nachbaur
Research23 Jan 2020
Leukemia

Volume: 34, P: 1885-1897
Reconciling material cultures in archaeology with genetic data requires robust cultural evolutionary taxonomies

Felix Riede
Christian Hoggard
Stephen Shennan
Comments & OpinionOpen Access28 May 2019
Palgrave Communications

Volume: 5, P: 1-9

Search

Challenging the Bredt’s rule in an acid catalyzed cationic cyclization to get bicyclo[3.3.1]nonane derivatives

Different distribution of pattern of 100-Å filaments in resting and locomotive leukaemia cells

T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

Assessing phototoxic drug properties of hydrochlorothiazide using human skin biopsies

Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial

Author Correction: Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial

Flexible quasi-2D perovskite solar cells with high specific power and improved stability for energy-autonomous drones

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

Understanding environmental trade-offs and resource demand of direct air capture technologies through comparative life-cycle assessment

Multivalents resulting from monobrachial homologies within a hybrid zone in Dichroplus pratensis (Acrididae): meiotic orientation and segregation

Genetic diagnosis of Mendelian disorders via RNA sequencing

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Integrating hybrid zone analyses in species delimitation: lessons from two anuran radiations of the Western Mediterranean

Emergence of mesoscale quantum phase transitions in a ferromagnet

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

AUGUR, a flexible and efficient optimization algorithm for identification of optimal adsorption sites

EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation

Active learning graph neural networks for partial charge prediction of metal-organic frameworks via dropout Monte Carlo

Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder

The metabolic nature of inflammatory bowel diseases

Social network architecture of human immune cells unveiled by quantitative proteomics

Defining clinical subgroups and genotype–phenotype correlations in NBAS-associated disease across 110 patients

Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity

Reconciling material cultures in archaeology with genetic data requires robust cultural evolutionary taxonomies

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