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Cell biology

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AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration

Cell migration depends on controlled adhesion turnover, but its regulation remains unclear. Here the authors show that AAK1 promotes focal adhesion disassembly via PDLIM5 and Talin1 phosphorylation, enabling efficient cell migration.

Daniela Krocianova
Alexander D. Dagg
Zuzana Kadlecova
ResearchOpen Access04 May 2026
Nature Communications

P: 1-22

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AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration

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