Nature Search

Fungi in cancer

In this Viewpoint article, we asked three scientists working on the cancer mycobiome to provide their opinions on advancements and challenges and what the future holds for this exciting field of cancer research.

Jessica Galloway-Peña
Iliyan D. Iliev
Florencia McAllister
Reviews12 Feb 2024
Nature Reviews Cancer

Volume: 24, P: 295-298
Correction to: Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer

Kanchan Singh
Melissa Pruski
Jennifer M. Bailey-Lundberg
Amendments and CorrectionsOpen Access02 Jun 2021
Laboratory Investigation

Volume: 101, P: 1304
A gut reaction can tune tumour fate during chemotherapy

The discovery that molecules produced by gut microorganisms can affect immune cells, and thus the success of chemotherapy for pancreatic cancer, points the way towards the use of nutritional interventions to improve outcomes.

Le Li
Florencia McAllister
News & Views22 Feb 2023
Nature

Volume: 615, P: 36-37
The liver casts a wide NET for metastatic pancreatic cancer

The liver can create a uniquely favorable milieu for early colonization by metastatic pancreatic cancer cells. A study now highlights mechanisms — such as neutrophil extracellular traps, or NETs — that drive this process; this could inform strategies for intercepting metastasis and improving survival.

Le Li
Florencia McAllister
Anirban Maitra
News & Views11 Jul 2024
Nature Medicine

Volume: 30, P: 2125-2126
Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

Given the association of gut microbiota dysbiosis with hypertriglyceridemic pancreatitis (HTGP), authors assess the gut microbial diversity of patients with HTGP, and provide immunological insight utilising a murine model.

Guanqun Li
Liwei Liu
Bei Sun
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

The classification of breast lesions as indolent or aggressive to tailor treatment is crucial. Here, the authors use single-cell transcriptomics and multiparametric imaging of a breast cancer mouse model, report distinct tumor-immune features for the two types of lesions, and suggest the role of IL-17 signaling in disease progression.

Vidya C. Sinha
Amanda L. Rinkenbaugh
Helen Piwnica-Worms
ResearchOpen Access18 Aug 2021
Nature Communications

Volume: 12, P: 1-17
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Enterotoxigenic Bacteroides fragilis, a bacterium from the intestinal flora, may promote colon tumor formation through a pathway that involves Stat3 expression and T helper type 17 immune responses.

Shaoguang Wu
Ki-Jong Rhee
Cynthia L Sears
Research23 Aug 2009
Nature Medicine

Volume: 15, P: 1016-1022
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

Shean J Aujla
Yvonne R Chan
Jay K Kolls
Research10 Feb 2008
Nature Medicine

Volume: 14, P: 275-281
Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer

In this study, the authors provide evidence that ectopic expression of oncogenic mutant Kras in pancreatic ducts generates early and late (PanIN) and pancreatic ductal adenocarcinoma (PDAC) . They characterized this Ras rheostat model which reveals elevated Kras mutation frequency and loss of PTEN are important drivers of PanIN and invasive ductal derived PDAC.

Kanchan Singh
Melissa Pruski
Jennifer M. Bailey-Lundberg
ResearchOpen Access02 Oct 2020
Laboratory Investigation

Volume: 101, P: 177-192
Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma

Ana De Jesus-Acosta
Elizabeth A. Sugar
Daniel A. Laheru
ResearchOpen Access20 Dec 2019
British Journal of Cancer

Volume: 122, P: 498-505
Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer

Kanchan Singh
Melissa A. Pruski
Jennifer M. Bailey
Research30 Sept 2019
Oncogene

Volume: 39, P: 1152-1164

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