The liver can create a uniquely favorable milieu for early colonization by metastatic pancreatic cancer cells. A study now highlights mechanisms — such as neutrophil extracellular traps, or NETs — that drive this process; this could inform strategies for intercepting metastasis and improving survival.
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References
Groot, V. P. et al. Ann. Surg. 267, 936–945 (2018).
Bojmar, L. et al. Nat. Med. https://doi.org/10.1038/s41591-024-03075-7 (2024).
Lee, J. W. et al. Nature 567, 249–252 (2019).
Costa-Silva, B. et al. Nat. Cell Biol. 17, 816–826 (2015).
Huby, T. & Gautier, E. L. Nat. Rev. Immunol. 22, 429–443 (2022).
Wang, G. Nature 618, 374–382 (2023).
Xue, R. et al. Nature 612, 141–147 (2022).
Adrover, J. M., McDowell, S. A. C., He, X. Y., Quail, D. F. & Egeblad, M. Cancer Cell 41, 505–526 (2023).
Yang, L. et al. Nature 583, 133–138 (2020).
Zhang, Y. et al. J. Exp. Med. 217, e210190354 (2020).
Mousset, A., Bellone, L., Gaggioli, C. & Albrengues, J. Trends Cancer https://doi.org/10.1016/j.trecan.2024.03.007 (2024).
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We thank E. Y. Faraoni for her valuable comments on this article.
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F.M. is a scientific advisory board member at Neologics Bio. A.M. is a consultant for Tezcat Biosciences and is named on a patent that has been licensed to ThriveEarlier Detection, an Exact Sciences Company. L.L declares no competing interests.
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Li, L., McAllister, F. & Maitra, A. The liver casts a wide NET for metastatic pancreatic cancer. Nat Med 30, 2125–2126 (2024). https://doi.org/10.1038/s41591-024-03112-5
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DOI: https://doi.org/10.1038/s41591-024-03112-5
