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Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

Methylmalonic acidemia is an inherited metabolic disease caused by loss or mutation of the enzyme MMUT. Here the authors use cell and animal models to show that MMUT mutations lead to defective mitophagy and stress in kidney cells, contributing to the pathogenesis in methylmalonic acidemia patients.

Alessandro Luciani
Anke Schumann
Olivier Devuyst
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-21
Potent Phagocytic Activity Discriminates Metastatic and Primary Human Malignant Melanomas: A Key Role of Ezrin

Luana Lugini
Francesco Lozupone
Stefano Fais
Research01 Nov 2003
Laboratory Investigation

Volume: 83, P: 1555-1567
Author Correction: Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

Alessandro Luciani
Anke Schumann
Olivier Devuyst
Amendments and CorrectionsOpen Access01 Apr 2020
Nature Communications

Volume: 11, P: 1
Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

De Leo et al. identify a lysosomal response to autophagic cargo during lysosome–autophagosome fusion that involves TLR9 activation and OCRL recruitment, and leads to a regulated local increase in PtdIns(4,5)P₂, which is necessary for a normal autophagic flux.

Maria Giovanna De Leo
Leopoldo Staiano
Maria Antonietta De Matteis
Research11 Jul 2016
Nature Cell Biology

Volume: 18, P: 839-850
Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

Melanoma patients harbouring BRAF^V600E mutation generally develop resistance to targeted therapy. In this study, the authors demonstrate that SREBP-1-mediated induction of lipid biosynthesis contributes to therapy resistance in BRAF mutant melanoma.

Ali Talebi
Jonas Dehairs
Johannes V. Swinnen
ResearchOpen Access27 Jun 2018
Nature Communications

Volume: 9, P: 1-11
A new paradigm for optimized experimental design in cIEF platforms aimed at an accurate robust and reliable mAbs charge-variant assessment

Marcello Belfiore
Alessandro Ascione
Francesca Luciani
ResearchOpen Access15 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Conserved epitopes with high HLA-I population coverage are targets of CD8⁺ T cells associated with high IFN-γ responses against all dengue virus serotypes

Thiruni N. Adikari
Francesca Di Giallonardo
Fabio Luciani
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study

Alessandro Rambaldi
Alessandra Iurlo
Silvia Di Tollo
ResearchOpen Access11 Feb 2020
Leukemia

Volume: 34, P: 2234-2237
Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer

Lorella Bonaccorsi
Paola Luciani
Alessandro Peri
Research01 Sept 2008
Laboratory Investigation

Volume: 88, P: 1049-1056
High HIV-1 diversity in immigrants resident in Italy (2008–2017)

Maria Teresa Maggiorella
Nunzia Sanarico
Serena Dell’Isola
ResearchOpen Access24 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells

Francesca Zalfa
Vincenzo Panasiti
Claudia Bagni
ResearchOpen Access16 Nov 2017
Cell Death & Disease

Volume: 8, P: e3169

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Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

Potent Phagocytic Activity Discriminates Metastatic and Primary Human Malignant Melanomas: A Key Role of Ezrin

Author Correction: Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

A new paradigm for optimized experimental design in cIEF platforms aimed at an accurate robust and reliable mAbs charge-variant assessment

Conserved epitopes with high HLA-I population coverage are targets of CD8⁺ T cells associated with high IFN-γ responses against all dengue virus serotypes

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study

Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer

High HIV-1 diversity in immigrants resident in Italy (2008–2017)

The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells

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