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Multiferroics, materials that exhibit two or more ferroic orders, are potentially useful for data storage if the coupling between these orders can be exploited. Here the authors elucidate how the magnetism in ferrimagnetic nanopillars can control the electric polarization of a surrounding matrix.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Magnonics aims to use the collective excitations of spins in magnetic materials, magnons, for information transfer and processing. In this manuscript, Elnaggar et al. study magnon excitations in hematite using resonant inelastic X-ray scattering, observing higher-order magnons.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

Binding of a sialoglycan-based primary receptor by the spike protein of the common cold human coronavirus HKU1 triggers conformational changes to a state that would allow binding to a second receptor required for cell entry.

The AcP10 protein—an active uridine kinase, encoded by the beluga whale coronavirus SW1—is an antagonist of the integrated stress response that acts downstream of phosphorylation of the translation initiation factor eIF2, irrespective of which eIF2 kinase is activated. AcP10 acts as a competitive inhibitor of the eIF2[P]–eIF2B interaction by binding to eIF2B. A protein with a similar function is also encoded by Aichivirus, a picornavirus.

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

A detailed understanding of solute–solvent interactions is crucial to appreciating the important role aqueous ions play in various biological and catalytic processes. Now soft X-ray spectroscopy reveals new features in aqueous ion spectra that are due to solute–solvent interaction and electron transfer.

Mutations in PPARγ lead to lipodystrophy, but the mechanisms by which the mutations affect the activity in chromatin is unknown. Here, Madsen, Broekema et al. showed that mutations affecting two intermolecular interactions compromise chromatin remodeling.

When electrons are transported through a semiconductor quantum dot, they interact with nuclear spin in the host material. This interaction—often considered to be a nuisance—is now shown to provide a feedback mechanism that actively pulls the electron-spin Larmor frequency into resonance with that of an external microwave driving field.

The cellular differentiation states of paediatric rhabdomyosarcoma (RMS) remain to be explored. Here, single-cell RNA sequencing analysis of RMS tumours reveals an immunosuppressive microenvironment and distinct transcriptional programs predictive of patient outcomes.

Human coronavirus OC43 causes respiratory disease and is maintained in the human population through recurring infections. Here, by extensive structural analyses, the authors provide insights into the binding sites and breadth of neutralizing antibodies against this endemic coronavirus.

Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

The authors provide a litmus test for the recognition mechanism of transiently binding proteins based on nuclear magnetic resonance and find a conformational selection binding mechanism through concentration-dependent kinetics of ubiquitin and SH3.

Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin domain covered with a putative glycan shield; and they discuss these features in the context of host adaptation.

Although magnetic molecules are widely investigated for their potential use in memory devices, their regular arrangement on surfaces has proven difficult. Arrays of iron atoms, linked by molecular ligands, have now been fabricated on copper surfaces. Importantly, the magnetism of the iron atoms is preserved and can be switched through oxygen adsorption.

The intermediate states in photo-excited phase transitions are expected to be inhomogeneous. However, ultrafast X-ray imaging shows the early part of the metal–insulator transition in VO₂ is homogeneous but then becomes heterogeneous.

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

Direct and real-time observation of the excess holes in an element-specific and energylevel-specific manner is a challenging task. Here the authors present a complete hole dynamics of photo-excited anatase TiO₂ with 100 femto-second resolution.

The modulation of single-atom catalyst properties for industrial applications remains challenging. Here, authors use strain engineering to amplify the synergistic effect between MoS₂’s sulphur vacancies and single-atom Ru sites and accelerate H₂ evolution electrocatalysis.

Analysis of the immunogenicity of the Ad26.COV2.S vaccine against the B1.351 and P.1 SARS-CoV-2 variants of concern shows reduced neutralization antibody titres, but comparable T cell responses and antibody-dependent effector functions.

While water splitting chemistry provides a renewable means to produce carbon-neutral hydrogen fuel, the most efficient catalysts require rare and expensive platinum. Here, authors prepare single-atom platinum on cobalt selenide as a high-performance hydrogen evolution electrocatalyst.

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

‘Tubuloids’ grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.

Design of efficient catalysts requires understanding the decisive electronic parameters for catalytic efficacy and their dependence on elemental composition. Here, the authors report covalency as suitable descriptor of perovskite-type transition metal oxides as chemo-catalysts.

Analyses of expression profiles from whole blood of 31,684 individuals identify cis-expression quantitative trait loci (eQTL) effects for 88% of genes and trans-eQTL effects for 37% of trait-associated variants.

High-angle annular dark-field scanning transmission electron microscopy, combined with electron energy-loss spectroscopy, can analyse both the organic and inorganic components of a hybrid nanoparticle.

Direct observation of the atomic and electronic structure of a single-atom catalyst is essential. Here, the authors report an oxyhydroxide stabilized iridium catalyst with superior oxygen evolution catalytic activity and identify the isolated iridium sites which promote the H₂O attack and O–O coupling.

Here, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTORC1 signalling as a major regulation network during virus infection.

Argon and luminescence dating of fossil shell infills from Trinil in Java, where Homo erectus lived, reveals that the hominin-bearing deposits are younger than previously thought; perforated shells, a shell tool and an engraved shell indicate that Homo erectus ate freshwater mussels, used their shells as tools and was able to create abstract engravings.

Tip60 is a transcriptional coregulator that has an important role in differentiation. Here, Gao et al. demonstrate that the deubiquitination of Tip60 by USP7, a dominant deubiquitinating enzyme, is a key mechanism in early adipogenesis regulation.

Metabolically active organelles compete for cytosolic space and resources during metabolism rewiring. Here, the authors develop a computational model of yeast metabolism and resource allocation to predict condition- and compartment-specific proteome constraints that govern metabolic strategies.

In the Big Data era, a change of paradigm in the use of molecular dynamics is required. Trajectories should be stored under FAIR (findable, accessible, interoperable and reusable) requirements to favor its reuse by the community under an open science paradigm.