Nature Search

Single ionic channels observed in tissue-cultured muscle

Deborah J. Nelson
Frederick Sachs
Research20 Dec 1979
Nature

Volume: 282, P: 861-863
Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential

A. Raz
C. Bucana
I. J. Fidler
Research27 Mar 1980
Nature

Volume: 284, P: 363-364
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Laura Schmidt
Fuh-Mei Duh
Berton Zbar
Research01 May 1997
Nature Genetics

Volume: 16, P: 68-73
Meiotic initiation by the mos protein in Xenopus

Nelson Yew
Michael L. Mellini
George F. Vande Woude
Research13 Feb 1992
Nature

Volume: 355, P: 649-652
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor

Michael Jeffers
Shahriar Koochekpour
George F Vande Woude
Research24 Nov 1998
Oncogene

Volume: 17, P: 2691-2700
Biomedical ethics 2.0: redefining the meaning of disease, patient and treatment

Frederick Grinnell argues that the era of molecular medicine has provoked new understanding of basic medical terms, necessitating an ‘upgrade’ to modern biomedical ethics.

Frederick Grinnell
Comments & Opinion17 Apr 2020
Nature Reviews Molecular Cell Biology

Volume: 21, P: 417-418
Gene structure of the human MET proto-oncogene

Fuh-Mei Duh
Stephen W Scherer
Laura Schmidt
Research25 Sept 1997
Oncogene

Volume: 15, P: 1583-1586
A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

Sergei I. Sukharev
Paul Blount
Ching Kung
Research17 Mar 1994
Nature

Volume: 368, P: 265-268
NIH funding

Frederick Sachs
Correspondence17 Jun 1993
Nature

Volume: 363, P: 578
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products

John Groffen
Nora Heisterkamp
John R. Stephenson
Research14 Jul 1983
Nature

Volume: 304, P: 167-169
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

Sam Thiagalingam
Christoph Lengauer
Bert Vogelstein
Research01 Jul 1996
Nature Genetics

Volume: 13, P: 343-346
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

Rong Zhang
Frederick W. Alt
Wojciech Swat
Research30 Mar 1995
Nature

Volume: 374, P: 470-473
Decreased fibronectin expression in Met/HGF-mediated tumorigenesis

Gregory A Taylor
Mike Jeffers
George F Vande Woude
Research04 Sept 1998
Oncogene

Volume: 17, P: 1179-1183
Limit the number of grants per person

Frederick Sachs
Correspondence17 Jul 1997
Nature

Volume: 388, P: 222
Tarantula peptide inhibits atrial fibrillation

A peptide from spider venom can prevent the heartbeat from losing its rhythm.

Frank Bode
Frederick Sachs
Michael R. Franz
Research04 Jan 2001
Nature

Volume: 409, P: 35-36
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

Stephen V. Desiderio
George D. Yancopoulos
David Baltimore
Research25 Oct 1984
Nature

Volume: 311, P: 752-755
Voltage-induced membrane movement

Ping-Cheng Zhang
Asbed M. Keleshian
Frederick Sachs
Research27 Sept 2001
Nature

Volume: 413, P: 428-432
Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.

Teresa Pérez-Berezo
Julien Pujo
Nicolas Cenac
ResearchOpen Access03 Nov 2017
Nature Communications

Volume: 8, P: 1-12
The sensation of stretch

Piezo proteins have been shown to form large ion channels that serve a sensory function in fruitflies. The findings help to explain how Piezos convert mechanical force into biological signals. See Article p.176 & Letter p.209

Philip A. Gottlieb
Frederick Sachs
News & Views07 Mar 2012
Nature

Volume: 483, P: 163-164
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers

Thomas M. Suchyna
Sonya E. Tape
Philip A. Gottlieb
Research08 Jul 2004
Nature

Volume: 430, P: 235-240
Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei

Micropillar patterns causing changes in the nuclear and cellular morphologies of human mesenchymal stromal cells influence the conformation of the cells’ chromatin and their osteogenic differentiation in vitro and in mice.

Xinlong Wang
Vasundhara Agrawal
Guillermo A. Ameer
Research12 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 1514-1529
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.

Charles D. Cox
Chilman Bae
Boris Martinac
ResearchOpen Access20 Jan 2016
Nature Communications

Volume: 7, P: 1-13
In defence of small science

Frederick Sachs
Comments & Opinion13 Nov 1997
Nature

Volume: 390, P: 203
Does a stretch-inactivated cation channel integrate osmotic and peptidergic signals?

Frederick Sachs
Catherine E. Morris
Owen Hamill
Correspondence01 Sept 2000
Nature Neuroscience

Volume: 3, P: 847
Retaining your identity under stress

Mechanosensitive ion channels from bacteria open like an iris, with the transmembrane helices tilting into the membrane to make a thin, wide structure with a 3 nm pore.

Frederick Sachs
News & Views01 Sept 2002
Nature Structural Biology

Volume: 9, P: 636-637
Molecular aspects of bacterial pH sensing and homeostasis

In this Review, Krulwich, Sachs and Padan describe how the evolution of diverse mechanisms for pH sensing and homeostasis has enabled bacteria to survive sudden changes in external pH and to grow in environments with external pH values that would otherwise be toxic.

Terry A. Krulwich
George Sachs
Etana Padan
Reviews05 Apr 2011
Nature Reviews Microbiology

Volume: 9, P: 330-343
Role of cholesterol and lipid organization in disease

Frederick R. Maxfield
Ira Tabas
Reviews30 Nov 2005
Nature

Volume: 438, P: 612-621
Three-color single-molecule localization microscopy in chromatin

We present a protocol enabling multi-color chromatin SMLM, revealing transcription and enhancer-associated euchromatin organizes around heterochromatic cores into functional volumes. This significantly advances nanoscopic molecular imaging within the nucleus.

Nicolas Acosta
Ruyi Gong
Vadim Backman
ResearchOpen Access17 Mar 2025
Light: Science & Applications

Volume: 14, P: 1-13
Defining the risk of SARS-CoV-2 variants on immune protection

The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

Marciela M. DeGrace
Elodie Ghedin
Mehul S. Suthar
Reviews31 Mar 2022
Nature

Volume: 605, P: 640-652
Adherent cell remodeling on micropatterns is modulated by Piezo1 channels

Deekshitha Jetta
Mohammad Reza Bahrani Fard
Susan Z. Hua
ResearchOpen Access03 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1

Mohammad M. Maneshi
Lynn Ziegler
Philip A. Gottlieb
ResearchOpen Access24 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Mechanical stress activates NMDA receptors in the absence of agonists

Mohammad Mehdi Maneshi
Bruce Maki
Susan Z. Hua
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

A Satyanarayana
P Kaldis
Reviews29 Jun 2009
Oncogene

Volume: 28, P: 2925-2939

Search

Single ionic channels observed in tissue-cultured muscle

Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Meiotic initiation by the mos protein in Xenopus

Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor

Biomedical ethics 2.0: redefining the meaning of disease, patient and treatment

Gene structure of the human MET proto-oncogene

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

NIH funding

Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

Decreased fibronectin expression in Met/HGF-mediated tumorigenesis

Limit the number of grants per person

Tarantula peptide inhibits atrial fibrillation

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

Voltage-induced membrane movement

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

The sensation of stretch

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers

Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

In defence of small science

Does a stretch-inactivated cation channel integrate osmotic and peptidergic signals?

Retaining your identity under stress

Molecular aspects of bacterial pH sensing and homeostasis

Role of cholesterol and lipid organization in disease

Three-color single-molecule localization microscopy in chromatin

Defining the risk of SARS-CoV-2 variants on immune protection

Adherent cell remodeling on micropatterns is modulated by Piezo1 channels

Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1

Mechanical stress activates NMDA receptors in the absence of agonists

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

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