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Signal Transduction and Targeted Therapy (1)
Nature Communications (1)

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Advanced filters: Author: Fujing Ge Clear advanced filters

Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer

The protein stability of KRAS mutants can influence tumor promotion. Here, the authors identify that deubiquitinase JOSD2 stabilizes KRAS mutants and JOSD2 depletion inhibits KRAS-mutant colorectal cancer growth in part due to mutant KRAS degradation.

Tao Yuan
Yue Liu
Bo Yang
ResearchOpen Access16 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Tao Yuan
Chenming Zeng
Bo Yang
ResearchOpen Access05 Jan 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-16

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Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

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