Nature Search

Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice

The glucagon receptor (GCGR) antagonism is a potential target for diabetes therapy but side effects such as α-cell hyperplasia and hyperglucagonemia limit therapeutic development. Here the authors report that GCGR antagonism leads to increased α-cell glucagon secretion at the single-cell level, dependent on VGF (VGF nerve growth factor inducible)

Jianxin Jia
Xuanxuan Bai
Mingyu Li
ResearchOpen Access12 Mar 2025
Nature Communications

Volume: 16, P: 1-17
A cuproptosis nanocapsule for cancer radiotherapy

Acquired radiation resistance in residual tumours impedes the therapeutic outcome of re-irradiation. This study reports a novel radiosensitization strategy that targets cuproptosis to overcome resistance and enhance antitumour effects.

You Liao
Dongmei Wang
Zhanjun Gu
Research19 Sept 2024
Nature Nanotechnology

Volume: 19, P: 1892-1902
Attribution Analysis of Runoff Change in Min-Tuo River Basin based on SWAT model simulations, China

Jian Hu
Jie Ma
Zhigang Wang
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-16
Experimental confirmation of driving pressure boosting and smoothing for hybrid-drive inertial fusion at the 100-kJ laser facility

In laser-driven inertial fusion, finding optimal driving pressure is a major challenge. Here, the authors use a 100 kJ SG laser and a hybrid-drive scheme to demonstrate such driving pressure with the help of the direct-drive laser such that the indirect-drive radiation ablation pressure is turned into a well-smoothed hybrid-drive pressure much greater than the radiation ablation pressure.

Ji Yan
Jiwei Li
Shaoping Zhu
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-9
MiR-485 targets the DTX4 gene to regulate milk fat synthesis in bovine mammary epithelial cells

Juan Liu
Ping Jiang
Zhihui Zhao
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-11
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its tetramerization but not that of full-length RXRα.

Liqun Chen
Alexander E. Aleshin
Xiao-kun Zhang
ResearchOpen Access17 Jul 2017
Nature Communications

Volume: 8, P: 1-14
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

A subtype of early-stage hepatocellular carcinoma characterized by disrupted cholesterol homeostasis and associated with a poor prognosis responds to treatment with the SOAT1 inhibitor avasimibe in a patient-derived xenograft mouse model.

Ying Jiang
Aihua Sun
Zesong Li
Research27 Feb 2019
Nature

Volume: 567, P: 257-261
A subpopulation of CD146⁺ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome

Lin Jing
Yunhe An
Hongxia Duan
ResearchOpen Access12 Jun 2023
Cellular & Molecular Immunology

Volume: 20, P: 908-923
Near telomere-to-telomere assembly of the Tarim pigeon (Columba livia) genome

Wenhao Yang
Hao Zhou
He Meng
ResearchOpen Access31 Dec 2024
Scientific Data

Volume: 11, P: 1-9
The influence of the mating type on virulence of Mucor irregularis

Wenqi Xu
Guanzhao Liang
Weida Liu
ResearchOpen Access06 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

Yuan Yin
Xing Cai
Chen-Yu Zhang
ResearchOpen Access16 Sept 2014
Cell Research

Volume: 24, P: 1164-1180

Search

Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice

A cuproptosis nanocapsule for cancer radiotherapy

Attribution Analysis of Runoff Change in Min-Tuo River Basin based on SWAT model simulations, China

Experimental confirmation of driving pressure boosting and smoothing for hybrid-drive inertial fusion at the 100-kJ laser facility

MiR-485 targets the DTX4 gene to regulate milk fat synthesis in bovine mammary epithelial cells

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

A subpopulation of CD146⁺ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome

Near telomere-to-telomere assembly of the Tarim pigeon (Columba livia) genome

The influence of the mating type on virulence of Mucor irregularis

Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

Search

Quick links

Search

Filter By:

Search

Quick links