Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Güneş Parlakgül Clear advanced filters

  • The endoplasmic reticulum (ER) is central to protein synthesis, folding and secretion. A study now shows that ageing is characterized by a striking loss of ER mass and remodelling of the ER structure. This shift is driven by tissue-specific ER-phagy, and may contribute to age-related loss of proteostasis.

    • Kalina Lapenta
    • Güneş Parlakgül
    • Ana Paula Arruda
    News & Views
    Nature Cell Biology
    P: 1-2

  • Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.

    • Güneş Parlakgül
    • Ana Paula Arruda
    • Gökhan S. Hotamışlıgil
    Research
    Nature
    Volume: 603, P: 736-742

  • Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver disease in humans.

    • Renata L. S. Goncalves
    • Zeqiu Branden Wang
    • Gökhan S. Hotamışlıgil
    Research
    Nature
    Volume: 643, P: 1057-1065

  • Hepatocytes are central for maintaining metabolic homeostasis during nutritional transitions. Here, we show that the structural remodelling of hepatic organelles is part of hepatocytes’ metabolic plasticity to adapt to cycles of fasting/feeding and this process is zonated in the liver.

    • Güneş Parlakgül
    • Song Pang
    • Ana Paula Arruda
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18