Nε-methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription, and understanding the extent to which histone Nε-methyllysine readers and erasers can manifest selectivity is of fundamental and medicinal interest. Here, the authors study the phosphonium analogue of Nε-trimethyllysine, finding that a subtle substitution from nitrogen to phosphorus substantially affects its interactions with Nε-methyllysine readers and erasers.
- Roman Belle
- Jos J. A. G. Kamps
- Jasmin Mecinović
