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Advanced filters: Author: Gabriel K. El Sebae Clear advanced filters

A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels

Epigenetic editing of PCSK9 in the liver, designed to induce DNA methylation and silence gene expression, achieved long-lasting reductions in LDL cholesterol levels in both transgenic mice expressing the human PCSK9 gene and cynomolgus monkeys.

Frederic Tremblay
Qiang Xiong
Aron B. Jaffe
ResearchOpen Access10 Feb 2025
Nature Medicine

Volume: 31, P: 1329-1338

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A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels

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