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Advanced filters: Author: Gek Ming Sia Clear advanced filters

Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice

Synapse loss is central to the pathogenesis of stress-related disorders. Here, the authors show that targeted synapse removal by microglia and complement during stress contributes to the effects of stress on behavior.

Haven Tillmon
Breeanne M. Soteros
Gek Ming Sia
ResearchOpen Access12 Nov 2024
Nature Communications

Volume: 15, P: 1-17
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

The complement–microglia pathway is a key mediator of synapse elimination in development and disease. Cong et al. show that neurons endogenously express a complement inhibitor, SRPX2, that regulates synapse elimination in development.

Qifei Cong
Breeanne M. Soteros
Gek-Ming Sia
Research13 Jul 2020
Nature Neuroscience

Volume: 23, P: 1067-1078

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Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

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